{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3(10)"],"submitter":["Yu T"],"pubmed_abstract":["Diabetes is a complex metabolic disorder characterized by persistent hyperglycemia, which causes damage to multiple target organs and triggers a range of complications. Oxidative stress, driven by reactive oxygen species (ROS) such as hypochlorite (HClO) and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), plays a crucial role in the onset and progression of diabetes and its associated complications. Therefore, the simultaneous and differential detection of HClO, H<sub>2</sub>O<sub>2</sub>, and their mixture is essential for accurately assessing oxidative stress status and understanding their synergistic roles in disease progression. In this study, we present a triple-signal fluorescent probe, probe <b>1</b>, designed to simultaneously and selectively detect HClO, H<sub>2</sub>O<sub>2</sub>"],"journal":["Chemical & biomedical imaging"],"pagination":["691-699"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12569950"],"repository":["biostudies-literature"],"pubmed_title":["A Smart Triple-Signal Fluorescent Probe for Real-Time Differential Imaging of HClO, H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;, and Their Mixture in Diabetic Models."],"pmcid":["PMC12569950"],"pubmed_authors":["Li H","Li Y","Zhang Y","Zhang X","Yin P","Yao S","Yu T","Deng Y"],"additional_accession":[]},"is_claimable":false,"name":"A Smart Triple-Signal Fluorescent Probe for Real-Time Differential Imaging of HClO, H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;, and Their Mixture in Diabetic Models.","description":"Diabetes is a complex metabolic disorder characterized by persistent hyperglycemia, which causes damage to multiple target organs and triggers a range of complications. Oxidative stress, driven by reactive oxygen species (ROS) such as hypochlorite (HClO) and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), plays a crucial role in the onset and progression of diabetes and its associated complications. Therefore, the simultaneous and differential detection of HClO, H<sub>2</sub>O<sub>2</sub>, and their mixture is essential for accurately assessing oxidative stress status and understanding their synergistic roles in disease progression. In this study, we present a triple-signal fluorescent probe, probe <b>1</b>, designed to simultaneously and selectively detect HClO, H<sub>2</sub>O<sub>2</sub>","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-05T09:34:22.229Z","creation":"2026-05-15T03:12:58.153Z"},"accession":"S-EPMC12569950","cross_references":{"pubmed":["41169451"],"doi":["10.1021/cbmi.5c00040"]}}