biostudies-literatureUnknown3(10)Yu TDiabetes is a complex metabolic disorder characterized by persistent hyperglycemia, which causes damage to multiple target organs and triggers a range of complications. Oxidative stress, driven by reactive oxygen species (ROS) such as hypochlorite (HClO) and hydrogen peroxide (H₂O₂), plays a crucial role in the onset and progression of diabetes and its associated complications. Therefore, the simultaneous and differential detection of HClO, H₂O₂, and their mixture is essential for accurately assessing oxidative stress status and understanding their synergistic roles in disease progression. In this study, we present a triple-signal fluorescent probe, probe <b>1</b>, designed to simultaneously and selectively detect HClO, H₂O₂Chemical & biomedical imaging691-699https://www.ebi.ac.uk/biostudies/studies/S-EPMC12569950biostudies-literatureA Smart Triple-Signal Fluorescent Probe for Real-Time Differential Imaging of HClO, H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;, and Their Mixture in Diabetic Models.PMC12569950Li HLi YZhang YZhang XYin PYao SYu TDeng YfalseA Smart Triple-Signal Fluorescent Probe for Real-Time Differential Imaging of HClO, H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;, and Their Mixture in Diabetic Models.Diabetes is a complex metabolic disorder characterized by persistent hyperglycemia, which causes damage to multiple target organs and triggers a range of complications. Oxidative stress, driven by reactive oxygen species (ROS) such as hypochlorite (HClO) and hydrogen peroxide (H₂O₂), plays a crucial role in the onset and progression of diabetes and its associated complications. Therefore, the simultaneous and differential detection of HClO, H₂O₂, and their mixture is essential for accurately assessing oxidative stress status and understanding their synergistic roles in disease progression. In this study, we present a triple-signal fluorescent probe, probe <b>1</b>, designed to simultaneously and selectively detect HClO, H₂O₂2025-01-01T00:00:00Z2025 Oct2026-06-05T09:34:22.229Z2026-05-15T03:12:58.153ZS-EPMC125699504116945110.1021/cbmi.5c00040