{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["van Gils V"],"funding":["UK Dementia Research Institute","Cure Alzheimer's Fund","Alzheimer's Drug Discovery Foundation","Innovative Medicines Initiatives","Health Holland","Swedish Research Council","Hjärnfonden, Sweden","Autonomous Government of Catalonia","Stiftelsen för Gamla Tjänarinnor","Marie Curie International Training Network","Alzheimer&apos;s Association","Olav Thon Foundation","EU/EFPIA Innovative Medicines Initiative Joint Undertaking","National MS Society","Union Joint Programme - Neurodegenerative Disease Research","Familjen Rönströms Stiftelse","Topsector Life Sciences &amp; Health","Care Research University College London Hospitals Biomedical Research Centre","Bluefield Project","Dutch Research Council (NWO)","Cure Alzheimer&apos;s Fund","the Erling-Persson Family Foundation","European Union's Horizon Europe research and innovation programme","Alzheimer's Association","Dutch National Dementia Strategy","Vetenskapsrådet","ZonMw","National Institute for Health","Marie Skłodowska-Curie","The Selfridges Group Foundation","European Community's Horizon H2020/2014 - 2020","Swedish State Support for Clinical Research"],"pagination":["e70804"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12573102"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(10)"],"pubmed_abstract":["<h4>Introduction</h4>It remains unclear whether diabetes mellitus (DM) is associated with Alzheimer's disease (AD) pathology and associated vascular burden.<h4>Methods</h4>We included cognitively normal (CN), mild cognitive impairment (MCI), and dementia individuals. We assessed associations between DM and AD biomarkers (amyloid beta [Aβ], phosphorylated tau-181 [p-tau181], total tau [t-tau], and medial temporal atrophy [MTA]) and vascular burden (white matter hyperintensities, microbleeds) by logistic regression. Secondary analyses assessed associations between DM and profiles of Aβ combined with p-tau181/t-tau/MTA/white matter hyperintensity/microbleeds.<h4>Results</h4>We included 5550 participants (65.8+-8.7 years, 8.7% DM). DM was associated with lower odds of abnormal AD biomarkers: A"],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["The association of diabetes with Alzheimer's disease biomarkers and vascular burden across European aging and memory clinic cohorts."],"pmcid":["PMC12573102"],"funding_grant_id":["#2023‐00356","860197","101034344","#2022‐01018","10510032120003","831434","115736","#ADSF-21-831381-C","JPND2021-00694","#10510032120003","101053962","#201809-2016862","#ADSF-24-1284328-C","#2019-02397","SG21‐818099‐EPAD","#2022-01018","#2019‐02397","#2023-00356","UKDRI-1003","#ADSF-21-831377-C","73305095007","#ADSF-21-831376-C","#LSHM20106","#FO2022-0270","#73305095007","847879","SG21-818099-EPAD"],"pubmed_authors":["van der Flier WM","Frolich L","Wallin A","Moonen J","Salas‐Salvado J","Streffer J","Vos SJB","Dalsgaard S","Jansen WJ","Engelborghs S","Bralten J","Ramakers IHGB","Lovestone S","Damian D","Franke B","Zetterberg H","Fanelli G","Legdeur N","Rouaud O","van Harten A","Hall A","Popp J","Poelmans G","Jimenez-Murcia S","Freund-Levi Y","van Gils V","Bullo M","Vandenberghe R","Tsolaki M","Veverova K","Fernandez‐Aranda F","den Braber A","Lleo A","Martinez-Lage P","Visser PJ","Hort J","Laakso M","Teunissen CE"],"additional_accession":[]},"is_claimable":false,"name":"The association of diabetes with Alzheimer's disease biomarkers and vascular burden across European aging and memory clinic cohorts.","description":"<h4>Introduction</h4>It remains unclear whether diabetes mellitus (DM) is associated with Alzheimer's disease (AD) pathology and associated vascular burden.<h4>Methods</h4>We included cognitively normal (CN), mild cognitive impairment (MCI), and dementia individuals. We assessed associations between DM and AD biomarkers (amyloid beta [Aβ], phosphorylated tau-181 [p-tau181], total tau [t-tau], and medial temporal atrophy [MTA]) and vascular burden (white matter hyperintensities, microbleeds) by logistic regression. Secondary analyses assessed associations between DM and profiles of Aβ combined with p-tau181/t-tau/MTA/white matter hyperintensity/microbleeds.<h4>Results</h4>We included 5550 participants (65.8+-8.7 years, 8.7% DM). DM was associated with lower odds of abnormal AD biomarkers: A","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-06T14:42:07.251Z","creation":"2026-06-01T03:06:39.628Z"},"accession":"S-EPMC12573102","cross_references":{"pubmed":["41165072"],"doi":["10.1002/alz.70804"]}}