{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(49)"],"submitter":["Jia C"],"pubmed_abstract":["This study presents an optimized synthetic pathway for suvorexant and establishes a robust method for the simultaneous determination of residual solvents. The synthesis commenced with chiral precursors, specifically (<i>R</i>)-3-(BOC-amino)butyric acid and <i>N</i>-benzyl glycine ethyl ester, employing a fragment splicing strategy. The target compound was synthesized through a sequence of nucleophilic reactions, BOC deprotection, cyclization, reduction, BOC protection, affinity substitution, and subsequent nucleophilic reactions, thereby circumventing the need for chiral separation. The post-treatment process was refined <i>via</i> recrystallization to yield the active pharmaceutical ingredient (API). For residual solvent analysis, a headspace gas chromatography (HS-GC) method was develope"],"journal":["RSC advances"],"pagination":["41597-41607"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12573263"],"repository":["biostudies-literature"],"pubmed_title":["Optimized synthesis of suvorexant and determination of eight residual solvents by headspace gas chromatography."],"pmcid":["PMC12573263"],"pubmed_authors":["Liu Y","Wang Q","Jia C","Shi W","Zheng A","Wang X","Yu Z","Zhao J"],"additional_accession":[]},"is_claimable":false,"name":"Optimized synthesis of suvorexant and determination of eight residual solvents by headspace gas chromatography.","description":"This study presents an optimized synthetic pathway for suvorexant and establishes a robust method for the simultaneous determination of residual solvents. The synthesis commenced with chiral precursors, specifically (<i>R</i>)-3-(BOC-amino)butyric acid and <i>N</i>-benzyl glycine ethyl ester, employing a fragment splicing strategy. The target compound was synthesized through a sequence of nucleophilic reactions, BOC deprotection, cyclization, reduction, BOC protection, affinity substitution, and subsequent nucleophilic reactions, thereby circumventing the need for chiral separation. The post-treatment process was refined <i>via</i> recrystallization to yield the active pharmaceutical ingredient (API). For residual solvent analysis, a headspace gas chromatography (HS-GC) method was develope","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-05T09:44:03.422Z","creation":"2026-05-15T03:12:01.191Z"},"accession":"S-EPMC12573263","cross_references":{"pubmed":["41181021"],"doi":["10.1039/d5ra06779k"]}}