{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(41)"],"submitter":["Lee Y"],"pubmed_abstract":["Oral delivery of cannabidiol (CBD) is challenging because of its poor water solubility and low bioavailability, which restrict its therapeutic potential. In this study, we used a CBD-loaded oil-in-water nanoemulsion prepared from octenyl succinate anhydride (OSA)-modified starch to address these challenges. The CBD-encapsulated nanoemulsion (CBD-NE) exhibited a uniform particle size of 39.18 ± 0.15 nm, high encapsulation efficiency of 99.80 ± 0.13%, and maintained colloidal stability during storage for 28 days. Simulated gastrointestinal digestion demonstrated that the bioaccessibility of CBD in CBD-NE was higher than that in unformulated CBD. Furthermore, <i>in vitro</i> experiments using RAW264.7 macrophages showed that CBD-NE significantly (<i>p</i> < 0.05) suppressed lipopolysaccharide"],"journal":["ACS omega"],"pagination":["48146-48154"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12573299"],"repository":["biostudies-literature"],"pubmed_title":["Cannabidiol Loaded Nanoemulsion with Improved Bioaccessibility and Anti-Inflammatory Activity."],"pmcid":["PMC12573299"],"pubmed_authors":["Song HY","Kim SH","Byun EB","Lee Y"],"additional_accession":[]},"is_claimable":false,"name":"Cannabidiol Loaded Nanoemulsion with Improved Bioaccessibility and Anti-Inflammatory Activity.","description":"Oral delivery of cannabidiol (CBD) is challenging because of its poor water solubility and low bioavailability, which restrict its therapeutic potential. In this study, we used a CBD-loaded oil-in-water nanoemulsion prepared from octenyl succinate anhydride (OSA)-modified starch to address these challenges. The CBD-encapsulated nanoemulsion (CBD-NE) exhibited a uniform particle size of 39.18 ± 0.15 nm, high encapsulation efficiency of 99.80 ± 0.13%, and maintained colloidal stability during storage for 28 days. Simulated gastrointestinal digestion demonstrated that the bioaccessibility of CBD in CBD-NE was higher than that in unformulated CBD. Furthermore, <i>in vitro</i> experiments using RAW264.7 macrophages showed that CBD-NE significantly (<i>p</i> < 0.05) suppressed lipopolysaccharide","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-05T09:43:00.588Z","creation":"2026-05-15T03:12:57.913Z"},"accession":"S-EPMC12573299","cross_references":{"pubmed":["41180072"],"doi":["10.1021/acsomega.5c04608"]}}