{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Heng Wu"],"pubmed_abstract":["<h4>Background</h4>The world is facing both an increasingly severe energy crisis and a growing problem of agricultural pollution. The utilization of agricultural waste by anaerobic digestion (AD), has received increasing attention. AD using representative waste cow dung results in total ammonia nitrogen (TAN) accumulation and inhibition of methanogens resulting in reduced CH<sub>4</sub> production. However, there is a lack of highly efficient in-situ biological domestication strategies to enhance the TAN tolerance of methanogens in AD systems.<h4>Results</h4>In this study, an incremental approach to gradually increasing the TAN concentration has been used for overcoming the problem. The results showed that at an ultra-high concentration of 6124.09 mg/L TAN, a 48-day domesticated AD system "],"journal":["Microbiome"],"pagination":["223"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12574047"],"repository":["biostudies-literature"],"pubmed_title":["An innovative strategy for overcoming ultra-high ammonia nitrogen inhibition on anaerobic methanogenesis via stepwise domestication."],"pmcid":["PMC12574047"],"pubmed_authors":["Yang X","Dong T","Yao Y","Chen J","Lv H","Guo X","Zhang H","Miao C","Li A","Yang C","Heng Wu","Qiu L"],"additional_accession":[]},"is_claimable":false,"name":"An innovative strategy for overcoming ultra-high ammonia nitrogen inhibition on anaerobic methanogenesis via stepwise domestication.","description":"<h4>Background</h4>The world is facing both an increasingly severe energy crisis and a growing problem of agricultural pollution. The utilization of agricultural waste by anaerobic digestion (AD), has received increasing attention. AD using representative waste cow dung results in total ammonia nitrogen (TAN) accumulation and inhibition of methanogens resulting in reduced CH<sub>4</sub> production. However, there is a lack of highly efficient in-situ biological domestication strategies to enhance the TAN tolerance of methanogens in AD systems.<h4>Results</h4>In this study, an incremental approach to gradually increasing the TAN concentration has been used for overcoming the problem. The results showed that at an ultra-high concentration of 6124.09 mg/L TAN, a 48-day domesticated AD system ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-05T09:50:20.046Z","creation":"2026-05-15T03:12:52.846Z"},"accession":"S-EPMC12574047","cross_references":{"pubmed":["41168776"],"doi":["10.1186/s40168-025-02255-y"]}}