biostudies-literatureUnknown15(10)Arabi YM<h4>Introduction</h4>Deep vein thrombosis (DVT) in critically ill patients is often undetected. However, it is unclear whether ultrasound surveillance for early detection of DVT in high-risk medical-surgical intensive care unit (ICU) patients improves patients' outcomes. The DETECT trial (Diagnosing deep-vein thrombosis early in critically ill patients) evaluates the effect of twice-weekly bilateral lower limb ultrasound compared to usual care on 90-day mortality of critically ill adult patients admitted to medical, surgical and trauma ICUs.<h4>Methods and analysis</h4>The DETECT trial is an international, parallel-group, open-label, randomised trial, which will recruit 1800 critically ill adults from over 14 hospitals in Saudi Arabia and Kuwait. Eligible patients will be allocated to twicBMJ opene104468https://www.ebi.ac.uk/biostudies/studies/S-EPMC12574397biostudies-literatureDiagnosing deep vein thrombosis early in critically ill patients (DETECT) trial: a protocol for a randomised controlled trial.PMC12574397Wael MKharaba AAlnasrallah SAhmed MGAlhemiani SMaghrabi KAmin SNAliAlqahtani MSAlshahrani MSAlqahtani SMallisho AMatrouk AAIbrahim FMAlqahtani MAl-Anazi HAldouhan JAhmed MAAlfaghm SAlfilfil WAl-Dawood AAlkhaldi FAl-Rasheadi MSAlmousa AMBadawy EIAlmuteb JAlenzi MBouderar IAbanumay FBubbas SAlhazzani WAbuhaimed JMChalabi JAl-Fares AAElhady MOrabi OASaudi Critical Care Trials GroupBokhari MFBin Humaid FMutari AAAbdulgader RAAl-Hameed FAldabas MMapusao CAyon SAbuillah WJasem BAAl-Aqeeli AAlHumedi HBeji OHAbabtain AAHassanin IMPiero MAlenezi FNawaf SBrembali MJAl Humedi HIEldin DSAlshahrani MSSAlHumaidan AAlnefaie BAlbinali MSadat MAlmazyad GArabi YMAlQahtani RMAlahmary FArdah HIAl-Filfil WAMAsonto LPAlHamzah MAlQahtani SYAlsakan AElfaki OAlsomali HBarnawi RAbduljabbar AHHumaid FBAlsomali MKhyyat MNasef ABlazquez CHAl-Obaidly FAltuwayjiri KAlattas AAAl-Enazi NSBuabbas SFRasool GHazem WBaisas MAlgathmy HAlahmari AMNeimatalla MNoor MAlolit SChamaa MAAlmehmadi SFSaeedAbo-Zaid MFAlageel NAAlmarshadi SAl Tamimi AAldohan MMJohani AATamimi AAAhmed EMAlgethamy HAlmuthaybiri FFAlmutairi BSAmer MAlmoghamsy YfalseDiagnosing deep vein thrombosis early in critically ill patients (DETECT) trial: a protocol for a randomised controlled trial.<h4>Introduction</h4>Deep vein thrombosis (DVT) in critically ill patients is often undetected. However, it is unclear whether ultrasound surveillance for early detection of DVT in high-risk medical-surgical intensive care unit (ICU) patients improves patients' outcomes. The DETECT trial (Diagnosing deep-vein thrombosis early in critically ill patients) evaluates the effect of twice-weekly bilateral lower limb ultrasound compared to usual care on 90-day mortality of critically ill adult patients admitted to medical, surgical and trauma ICUs.<h4>Methods and analysis</h4>The DETECT trial is an international, parallel-group, open-label, randomised trial, which will recruit 1800 critically ill adults from over 14 hospitals in Saudi Arabia and Kuwait. Eligible patients will be allocated to twic2025-01-01T00:00:00Z2025 Oct2026-06-05T09:31:32.019Z2026-05-15T03:12:51.879ZS-EPMC125743974116182410.1136/bmjopen-2025-104468