{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Couvrette LJ"],"pubmed_abstract":["Spinal cord injury (SCI) is a debilitating neurological condition with far-reaching consequences for patients, including loss of motor function and significant limitations to quality of life. Implantable biomaterials have emerged as a therapeutic strategy to modulate the SCI microenvironment and facilitate regeneration of axons. In this study, plant-derived lignocellulosic scaffolds coated with poly-L-ornithine (PLO) are shown to support locomotor recovery and neural tissue repair in a rat model of spinal cord injury. Upon complete transection of the spinal cord, animals were implanted with a plant-derived scaffold coated in PLO, a positively charged amino acid chain that is known to promote neural stem cell differentiation into neurons and enhance myelin regeneration. Recovery of motor fu"],"journal":["Scientific reports"],"pagination":["38080"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12575751"],"repository":["biostudies-literature"],"pubmed_title":["Poly-L-Ornithine coated plant scaffolds support motor recovery in rats after traumatic spinal cord injury."],"pmcid":["PMC12575751"],"pubmed_authors":["Laliberte AM","Pelling AE","Modulevsky DJ","Bui TV","Monty R","Cuerrier CM","Galuta A","Obhi RK","Bayat A","Shore I","Tsai EC","Walker KLA","Couvrette LJ","Hickey RJ","Boudria R","Leblanc-Latour M"],"additional_accession":[]},"is_claimable":false,"name":"Poly-L-Ornithine coated plant scaffolds support motor recovery in rats after traumatic spinal cord injury.","description":"Spinal cord injury (SCI) is a debilitating neurological condition with far-reaching consequences for patients, including loss of motor function and significant limitations to quality of life. Implantable biomaterials have emerged as a therapeutic strategy to modulate the SCI microenvironment and facilitate regeneration of axons. In this study, plant-derived lignocellulosic scaffolds coated with poly-L-ornithine (PLO) are shown to support locomotor recovery and neural tissue repair in a rat model of spinal cord injury. Upon complete transection of the spinal cord, animals were implanted with a plant-derived scaffold coated in PLO, a positively charged amino acid chain that is known to promote neural stem cell differentiation into neurons and enhance myelin regeneration. Recovery of motor fu","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-05T08:51:36.199Z","creation":"2026-05-14T03:12:59.206Z"},"accession":"S-EPMC12575751","cross_references":{"pubmed":["41168240"],"doi":["10.1038/s41598-025-21856-z"]}}