biostudies-literatureUnknown15(1)Couvrette LJSpinal cord injury (SCI) is a debilitating neurological condition with far-reaching consequences for patients, including loss of motor function and significant limitations to quality of life. Implantable biomaterials have emerged as a therapeutic strategy to modulate the SCI microenvironment and facilitate regeneration of axons. In this study, plant-derived lignocellulosic scaffolds coated with poly-L-ornithine (PLO) are shown to support locomotor recovery and neural tissue repair in a rat model of spinal cord injury. Upon complete transection of the spinal cord, animals were implanted with a plant-derived scaffold coated in PLO, a positively charged amino acid chain that is known to promote neural stem cell differentiation into neurons and enhance myelin regeneration. Recovery of motor fuScientific reports38080https://www.ebi.ac.uk/biostudies/studies/S-EPMC12575751biostudies-literaturePoly-L-Ornithine coated plant scaffolds support motor recovery in rats after traumatic spinal cord injury.PMC12575751Laliberte AMPelling AEModulevsky DJBui TVMonty RCuerrier CMGaluta AObhi RKBayat AShore ITsai ECWalker KLACouvrette LJHickey RJBoudria RLeblanc-Latour MfalsePoly-L-Ornithine coated plant scaffolds support motor recovery in rats after traumatic spinal cord injury.Spinal cord injury (SCI) is a debilitating neurological condition with far-reaching consequences for patients, including loss of motor function and significant limitations to quality of life. Implantable biomaterials have emerged as a therapeutic strategy to modulate the SCI microenvironment and facilitate regeneration of axons. In this study, plant-derived lignocellulosic scaffolds coated with poly-L-ornithine (PLO) are shown to support locomotor recovery and neural tissue repair in a rat model of spinal cord injury. Upon complete transection of the spinal cord, animals were implanted with a plant-derived scaffold coated in PLO, a positively charged amino acid chain that is known to promote neural stem cell differentiation into neurons and enhance myelin regeneration. Recovery of motor fu2025-01-01T00:00:00Z2025 Oct2026-06-05T08:51:36.199Z2026-05-14T03:12:59.206ZS-EPMC125757514116824010.1038/s41598-025-21856-z