{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["He X"],"funding":["Guangdong Laboratory for Lingnan Modern Agriculture","Strategic Priority Research Program of the Chinese Academy of Sciences","National Key R&D Program of China","New Cornerstone Science Foundation","National Natural Science Foundation of China","National Key Research and Development Program of China","Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops"],"pagination":["5252-5278"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12576463"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(11)"],"pubmed_abstract":["Polyploidisation is a natural evolutionary mechanism that enhances plant stress tolerance and environmental adaptability; however, its impact on microbiome homeostasis remains poorly understood. In this study, we selected a nascent euploid synthetic hexaploid wheat line (HG116; 2n = 6x = 42, BBAADD) by selfing a triploid F1 hybrid of Triticum turgidum L. ssp. durum (Langdon, LDN; 2n = 4x = 28, BBAA) and Aegilops tauschii Coss. (SY41; 2n = 2x = 14, DD). We investigated the effects of synthetic polyploidisation on gene expression in roots, the root-associated microbiome and tolerance to Fusarium graminearum. Transcriptomic analysis revealed that polyploidisation in HG116 predominantly upregulated genes, which were enriched in stress- and defence-related pathways, particularly those involved "],"journal":["Plant biotechnology journal"],"pubmed_title":["Synthetic Polyploidisation Enhances Fusarium graminearum Tolerance in Wheat by Reshaping the Transcriptome and Strengthening the Microbiome."],"pmcid":["PMC12576463"],"funding_grant_id":["32370016","32425001","XDB0630000","32088102","FCBRCE-202506","NT2025003","2022YFF1001800","NCI202248","2023YFF1002200"],"pubmed_authors":["Li H","Shen J","Dong Z","Wang E","An G","Jiang M","Nie F","Zhou Y","Chen Z","He X","Zhang X","Wang X","Sun K"],"additional_accession":[]},"is_claimable":false,"name":"Synthetic Polyploidisation Enhances Fusarium graminearum Tolerance in Wheat by Reshaping the Transcriptome and Strengthening the Microbiome.","description":"Polyploidisation is a natural evolutionary mechanism that enhances plant stress tolerance and environmental adaptability; however, its impact on microbiome homeostasis remains poorly understood. In this study, we selected a nascent euploid synthetic hexaploid wheat line (HG116; 2n = 6x = 42, BBAADD) by selfing a triploid F1 hybrid of Triticum turgidum L. ssp. durum (Langdon, LDN; 2n = 4x = 28, BBAA) and Aegilops tauschii Coss. (SY41; 2n = 2x = 14, DD). We investigated the effects of synthetic polyploidisation on gene expression in roots, the root-associated microbiome and tolerance to Fusarium graminearum. Transcriptomic analysis revealed that polyploidisation in HG116 predominantly upregulated genes, which were enriched in stress- and defence-related pathways, particularly those involved ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T07:17:12.246Z","creation":"2026-05-14T03:08:30.238Z"},"accession":"S-EPMC12576463","cross_references":{"pubmed":["40783810"],"doi":["10.1111/pbi.70295"]}}