{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Blasczyk H"],"funding":["NIAID NIH HHS","National Institutes of Health","Canadian Institutes of Health Research"],"pagination":["e178089"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12578392"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["135(21)"],"pubmed_abstract":["Sustained CD4+ T cell immunity is required for resolution of acute hepatitis C virus (HCV) infection, but the response remains poorly characterized. Here, circulating CD4+ T cells with high programmed cell death 1 (PD-1) and ICOS coexpression were temporally associated with onset of virus control, seroconversion, and hepatitis in HCV-infected chimpanzees. Coproduction of T follicular helper (Tfh) (IL-21 and CXCL13) and Th1 (IFN-γ and TNF) cytokines after stimulation with HCV nonstructural proteins demonstrated that the response was predominately Tfh1 like and virus specific. Transcriptional analysis verified a Tfh1 lineage assignment. Effector-related genes such as ADGRG1 (GPR56), ZNF683 (Hobit), and KLRB1 (CD161) were also expressed. HCV-specific PD-1hiICOShi CD4+ Tfh1-like cells were enr"],"journal":["The Journal of clinical investigation"],"pubmed_title":["A liver-infiltrating CD4+ Tfh1 cell response predicts HCV control, hepatitis, and seroconversion during acute infection."],"pmcid":["PMC12578392"],"funding_grant_id":["U01AI131313","R01 AI126890","U19AI159819","R01AI136533","U19 AI159819","PJT-173467","U01 AI131313","R01 AI136533","R01AI190069","R01AI126890","R01 AI190069"],"pubmed_authors":["Blasczyk H","Bremer W","Phelps CC","Skinner N","Bowen DG","Lanford R","Grakoui A","Walker CM","Zhou Y","Xu Z","Shoukry NH"],"additional_accession":[]},"is_claimable":false,"name":"A liver-infiltrating CD4+ Tfh1 cell response predicts HCV control, hepatitis, and seroconversion during acute infection.","description":"Sustained CD4+ T cell immunity is required for resolution of acute hepatitis C virus (HCV) infection, but the response remains poorly characterized. Here, circulating CD4+ T cells with high programmed cell death 1 (PD-1) and ICOS coexpression were temporally associated with onset of virus control, seroconversion, and hepatitis in HCV-infected chimpanzees. Coproduction of T follicular helper (Tfh) (IL-21 and CXCL13) and Th1 (IFN-γ and TNF) cytokines after stimulation with HCV nonstructural proteins demonstrated that the response was predominately Tfh1 like and virus specific. Transcriptional analysis verified a Tfh1 lineage assignment. Effector-related genes such as ADGRG1 (GPR56), ZNF683 (Hobit), and KLRB1 (CD161) were also expressed. HCV-specific PD-1hiICOShi CD4+ Tfh1-like cells were enr","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T07:18:38.855Z","creation":"2026-05-14T03:08:47.406Z"},"accession":"S-EPMC12578392","cross_references":{"pubmed":["40956619"],"doi":["10.1172/JCI178089"]}}