{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hassan I"],"funding":["Ongoing Research Funding Program at King Saud University, Riyadh"],"pagination":["2601-2612"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12580169"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["45(12)"],"pubmed_abstract":["Potassium bromate (PB) is a well-known additive in the food industry and a byproduct of water treatment. Its long-term exposure to any form of life exerts mild to severe toxic insults in a dose-dependent fashion and can even trigger carcinogenesis. This study examines the ameliorative effectiveness of a prominent polyphenol, naringenin (NIR), in rodents previously exposed to PB. The Swiss albino rats were assigned to five treatment groups (n = 5): Group I was the control, and Groups II and III were administered with PB alone (100 mg/kg) and NIR alone (2 mg/kg), respectively. The remaining two groups were treated with NIR at 2 and 4 mg/kg in the PB-preadministered rats. The animals were sacrificed after the treatment course to retrieve their liver and blood for biochemical, molecular, and h"],"journal":["Journal of applied toxicology : JAT"],"pubmed_title":["Effect of Naringenin on Potassium Bromate-Induced Hepatotoxicity In Vivo: A Dose-Dependent Study."],"pmcid":["PMC12580169"],"funding_grant_id":["ORF-2025-366"],"pubmed_authors":["Islam BU","Awad EM","Ebaid H","Alhazza IM","Khan A","Hassan I","Al-Tamimi J"],"additional_accession":[]},"is_claimable":false,"name":"Effect of Naringenin on Potassium Bromate-Induced Hepatotoxicity In Vivo: A Dose-Dependent Study.","description":"Potassium bromate (PB) is a well-known additive in the food industry and a byproduct of water treatment. Its long-term exposure to any form of life exerts mild to severe toxic insults in a dose-dependent fashion and can even trigger carcinogenesis. This study examines the ameliorative effectiveness of a prominent polyphenol, naringenin (NIR), in rodents previously exposed to PB. The Swiss albino rats were assigned to five treatment groups (n = 5): Group I was the control, and Groups II and III were administered with PB alone (100 mg/kg) and NIR alone (2 mg/kg), respectively. The remaining two groups were treated with NIR at 2 and 4 mg/kg in the PB-preadministered rats. The animals were sacrificed after the treatment course to retrieve their liver and blood for biochemical, molecular, and h","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-05T09:48:43.739Z","creation":"2026-05-15T03:12:32.298Z"},"accession":"S-EPMC12580169","cross_references":{"pubmed":["40682247"],"doi":["10.1002/jat.4856"]}}