biostudies-literatureHassan IOngoing Research Funding Program at King Saud University, Riyadh2601-2612https://www.ebi.ac.uk/biostudies/studies/S-EPMC12580169biostudies-literatureUnknown45(12)Potassium bromate (PB) is a well-known additive in the food industry and a byproduct of water treatment. Its long-term exposure to any form of life exerts mild to severe toxic insults in a dose-dependent fashion and can even trigger carcinogenesis. This study examines the ameliorative effectiveness of a prominent polyphenol, naringenin (NIR), in rodents previously exposed to PB. The Swiss albino rats were assigned to five treatment groups (n = 5): Group I was the control, and Groups II and III were administered with PB alone (100 mg/kg) and NIR alone (2 mg/kg), respectively. The remaining two groups were treated with NIR at 2 and 4 mg/kg in the PB-preadministered rats. The animals were sacrificed after the treatment course to retrieve their liver and blood for biochemical, molecular, and hJournal of applied toxicology : JATEffect of Naringenin on Potassium Bromate-Induced Hepatotoxicity In Vivo: A Dose-Dependent Study.PMC12580169ORF-2025-366Islam BUAwad EMEbaid HAlhazza IMKhan AHassan IAl-Tamimi JfalseEffect of Naringenin on Potassium Bromate-Induced Hepatotoxicity In Vivo: A Dose-Dependent Study.Potassium bromate (PB) is a well-known additive in the food industry and a byproduct of water treatment. Its long-term exposure to any form of life exerts mild to severe toxic insults in a dose-dependent fashion and can even trigger carcinogenesis. This study examines the ameliorative effectiveness of a prominent polyphenol, naringenin (NIR), in rodents previously exposed to PB. The Swiss albino rats were assigned to five treatment groups (n = 5): Group I was the control, and Groups II and III were administered with PB alone (100 mg/kg) and NIR alone (2 mg/kg), respectively. The remaining two groups were treated with NIR at 2 and 4 mg/kg in the PB-preadministered rats. The animals were sacrificed after the treatment course to retrieve their liver and blood for biochemical, molecular, and h2025-01-01T00:00:00Z2025 Dec2026-06-05T09:48:43.739Z2026-05-15T03:12:32.298ZS-EPMC125801694068224710.1002/jat.4856