biostudies-literatureUnknown12Wang T<h4>Objective</h4>This study aimed to systematically analyze the morbidity and mortality of infectious diarrhea in children under 14 years old caused by pathogenic microorganisms globally and their temporal trends.<h4>Methods</h4>This study was a retrospective cross-sectional analysis using the database provided by the Global Burden of Disease 2021 (GBD 2021). The mortality, morbidity, and disability-adjusted life years (DALYs) of childhood diarrhea from 1990 to 2021 were stratified and analyzed using multivariate regression models and the calculation of estimated annual percentage change (EAPC).<h4>Results</h4>In 2021, the total number of cases of diarrhea in children aged 0-14 years worldwide was 168.73 million. The number of cases was highest in low- and medium-SDI regions, and the inciFrontiers in medicine1676249https://www.ebi.ac.uk/biostudies/studies/S-EPMC12580197biostudies-literatureRegional and age-specific global trends associated with infectious diarrhea in children under 14 years old caused by pathogenic microorganisms in 2021.PMC12580197Li HSang XLu WLi SWang TRen YXu THuang QWang LXiao AWu XfalseRegional and age-specific global trends associated with infectious diarrhea in children under 14 years old caused by pathogenic microorganisms in 2021.<h4>Objective</h4>This study aimed to systematically analyze the morbidity and mortality of infectious diarrhea in children under 14 years old caused by pathogenic microorganisms globally and their temporal trends.<h4>Methods</h4>This study was a retrospective cross-sectional analysis using the database provided by the Global Burden of Disease 2021 (GBD 2021). The mortality, morbidity, and disability-adjusted life years (DALYs) of childhood diarrhea from 1990 to 2021 were stratified and analyzed using multivariate regression models and the calculation of estimated annual percentage change (EAPC).<h4>Results</h4>In 2021, the total number of cases of diarrhea in children aged 0-14 years worldwide was 168.73 million. The number of cases was highest in low- and medium-SDI regions, and the inci2025-01-01T00:00:00Z20252026-06-05T11:55:01.488Z2026-05-16T03:12:57.482ZS-EPMC125801974118988610.3389/fmed.2025.1676249