{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bjorklund J"],"funding":["HUS Diagnostic center","Suomen kliinisen kemian yhdistys","Laboratoriolääketieteen Edistämissäätiö sr"],"pagination":["e70411"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12581111"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["32(11)"],"pubmed_abstract":["<h4>Background</h4>Kappa free light chain (KFLC)-based Kappa-index (K-index) can substitute oligoclonal banding (OCB) to detect intrathecal immunoglobulin synthesis. Cutoffs for positive results vary; therefore, further comparison of different approaches is necessary to optimize K-index for diagnostic utilization.<h4>Methods</h4>We analyzed 432 paired CSF/serum samples and selected 77 OCB-positive patients with multiple sclerosis (MS), clinically isolated syndrome (CIS) that did not progress to MS in > 10 years, and other neuroinflammatory diseases (non-MS). K-index subtests were measured on the Optilite platform (The Binding Site) and OCB with isoelectric focusing on the Hydrasys platform (Sebia).<h4>Results</h4>OCB positive cases had a higher K-index than OCB negative. The MS group had a"],"journal":["European journal of neurology"],"pubmed_title":["Optimized Kappa-Index Test Protocol to Detect Intrathecal Immunoglobulin Synthesis in Multiple Sclerosis."],"pmcid":["PMC12581111"],"funding_grant_id":["HUS/24/2024"],"pubmed_authors":["Bjorklund J","Osterlund-Tauriala E","Anttonen M","Siuko M","Itkonen O","Tienari PJ","Nokelainen P"],"additional_accession":[]},"is_claimable":false,"name":"Optimized Kappa-Index Test Protocol to Detect Intrathecal Immunoglobulin Synthesis in Multiple Sclerosis.","description":"<h4>Background</h4>Kappa free light chain (KFLC)-based Kappa-index (K-index) can substitute oligoclonal banding (OCB) to detect intrathecal immunoglobulin synthesis. Cutoffs for positive results vary; therefore, further comparison of different approaches is necessary to optimize K-index for diagnostic utilization.<h4>Methods</h4>We analyzed 432 paired CSF/serum samples and selected 77 OCB-positive patients with multiple sclerosis (MS), clinically isolated syndrome (CIS) that did not progress to MS in > 10 years, and other neuroinflammatory diseases (non-MS). K-index subtests were measured on the Optilite platform (The Binding Site) and OCB with isoelectric focusing on the Hydrasys platform (Sebia).<h4>Results</h4>OCB positive cases had a higher K-index than OCB negative. The MS group had a","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T11:32:24.762Z","creation":"2026-05-16T03:12:22.458Z"},"accession":"S-EPMC12581111","cross_references":{"pubmed":["41181945"],"doi":["10.1111/ene.70411"]}}