{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen L"],"funding":["China Scholarship Council","Deutsche Forschungsgemeinschaft"],"pagination":["454-467"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12583237"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["176(4)"],"pubmed_abstract":["CD73 is a membrane bound ectoenzyme, dephosphorylating adenosine mono- and di-phosphate to immunosuppressive adenosine. It is strongly expressed by CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells, but when analysing conventional CD4<sup>+</sup> T cells only 50% express CD73. When analysing these two clearly distinct (i.e., CD73<sup>+</sup> and CD73<sup>-</sup>) populations, we found that the naïve CD73<sup>+</sup>CD4<sup>+</sup> subset exerted superior proliferation over the CD73<sup>-</sup>CD4<sup>+</sup> cells, was more resistant to activation induced cells death (AICD) and was prone to develop into a \"Th1-like\" cell type, expressing the prototypic cytokines (IFN-γ, TNF-α) and specific transcription factors (i.e., Tbx21). Upon transfer into lymphopenic hosts, CD73<sup"],"journal":["Immunology"],"pubmed_title":["CD73 Expression by CD4 &lt;sup&gt;+&lt;/sup&gt; T Cells Marks Early Effector Memory T Cells."],"pmcid":["PMC12583237"],"funding_grant_id":["TRR 156, 444609457, 532695030","TRR 156 C04, TRR156B03-246807620","TRR 156 C04, TRR156B03‐246807620","202006320072"],"pubmed_authors":["Mahnke K","Chen L","Kurschus FC","Jurga A","Ring S","Enk A"],"additional_accession":[]},"is_claimable":false,"name":"CD73 Expression by CD4 &lt;sup&gt;+&lt;/sup&gt; T Cells Marks Early Effector Memory T Cells.","description":"CD73 is a membrane bound ectoenzyme, dephosphorylating adenosine mono- and di-phosphate to immunosuppressive adenosine. It is strongly expressed by CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells, but when analysing conventional CD4<sup>+</sup> T cells only 50% express CD73. When analysing these two clearly distinct (i.e., CD73<sup>+</sup> and CD73<sup>-</sup>) populations, we found that the naïve CD73<sup>+</sup>CD4<sup>+</sup> subset exerted superior proliferation over the CD73<sup>-</sup>CD4<sup>+</sup> cells, was more resistant to activation induced cells death (AICD) and was prone to develop into a \"Th1-like\" cell type, expressing the prototypic cytokines (IFN-γ, TNF-α) and specific transcription factors (i.e., Tbx21). Upon transfer into lymphopenic hosts, CD73<sup","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-05T11:36:29.523Z","creation":"2026-05-16T03:11:51.258Z"},"accession":"S-EPMC12583237","cross_references":{"pubmed":["40572025"],"doi":["10.1111/imm.70011"]}}