biostudies-literatureChen LChina Scholarship CouncilDeutsche Forschungsgemeinschaft454-467https://www.ebi.ac.uk/biostudies/studies/S-EPMC12583237biostudies-literatureUnknown176(4)CD73 is a membrane bound ectoenzyme, dephosphorylating adenosine mono- and di-phosphate to immunosuppressive adenosine. It is strongly expressed by CD4⁺CD25⁺Foxp3⁺ regulatory T cells, but when analysing conventional CD4⁺ T cells only 50% express CD73. When analysing these two clearly distinct (i.e., CD73⁺ and CD73^-) populations, we found that the naïve CD73⁺CD4⁺ subset exerted superior proliferation over the CD73^-CD4⁺ cells, was more resistant to activation induced cells death (AICD) and was prone to develop into a "Th1-like" cell type, expressing the prototypic cytokines (IFN-γ, TNF-α) and specific transcription factors (i.e., Tbx21). Upon transfer into lymphopenic hosts, CD73<supImmunologyCD73 Expression by CD4 &lt;sup&gt;+&lt;/sup&gt; T Cells Marks Early Effector Memory T Cells.PMC12583237TRR 156, 444609457, 532695030TRR 156 C04, TRR156B03-246807620TRR 156 C04, TRR156B03‐246807620202006320072Mahnke KChen LKurschus FCJurga ARing SEnk AfalseCD73 Expression by CD4 &lt;sup&gt;+&lt;/sup&gt; T Cells Marks Early Effector Memory T Cells.CD73 is a membrane bound ectoenzyme, dephosphorylating adenosine mono- and di-phosphate to immunosuppressive adenosine. It is strongly expressed by CD4⁺CD25⁺Foxp3⁺ regulatory T cells, but when analysing conventional CD4⁺ T cells only 50% express CD73. When analysing these two clearly distinct (i.e., CD73⁺ and CD73^-) populations, we found that the naïve CD73⁺CD4⁺ subset exerted superior proliferation over the CD73^-CD4⁺ cells, was more resistant to activation induced cells death (AICD) and was prone to develop into a "Th1-like" cell type, expressing the prototypic cytokines (IFN-γ, TNF-α) and specific transcription factors (i.e., Tbx21). Upon transfer into lymphopenic hosts, CD73<sup2025-01-01T00:00:00Z2025 Dec2026-06-05T11:36:29.523Z2026-05-16T03:11:51.258ZS-EPMC125832374057202510.1111/imm.70011