{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guo Q"],"funding":["National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["500"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12583464"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["Diabetes mellitus (DM) exacerbates periodontitis as the high-glucose (HG) environment aggravates local inflammation and periodontal bone resorption. Restoring periodontal homeostasis and promoting periodontal bone repair/regeneration are major challenges for the treatment of diabetic periodontitis. This study introduces antler stem cell-derived exosomes (AnSC-exos) as a potent therapeutic for treating diabetic periodontitis via leveraging the shared cranial neural crest cell (CNCC) origin of antlers and periodontal tissues. Using a rat model of diabetic periodontitis, we demonstrate that AnSC-exos effectively alleviate tissue abnormalities and alveolar bone destruction and resorption in periodontitis under DM conditions; the outcome was significantly more potent than human bone marrow mese"],"journal":["Cell death discovery"],"pubmed_title":["Antler stem cell-derived exosomes restore periodontal homeostasis in a rat model with diabetic periodontitis through enhancing ROS scavenging and osteogenesis."],"pmcid":["PMC12583464"],"funding_grant_id":["32301151","32470892"],"pubmed_authors":["Zhang G","Li J","Li C","Ren J","Gao L","Ba H","Libonati A","Shen Y","Guo Q","Ren S","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"Antler stem cell-derived exosomes restore periodontal homeostasis in a rat model with diabetic periodontitis through enhancing ROS scavenging and osteogenesis.","description":"Diabetes mellitus (DM) exacerbates periodontitis as the high-glucose (HG) environment aggravates local inflammation and periodontal bone resorption. Restoring periodontal homeostasis and promoting periodontal bone repair/regeneration are major challenges for the treatment of diabetic periodontitis. This study introduces antler stem cell-derived exosomes (AnSC-exos) as a potent therapeutic for treating diabetic periodontitis via leveraging the shared cranial neural crest cell (CNCC) origin of antlers and periodontal tissues. Using a rat model of diabetic periodontitis, we demonstrate that AnSC-exos effectively alleviate tissue abnormalities and alveolar bone destruction and resorption in periodontitis under DM conditions; the outcome was significantly more potent than human bone marrow mese","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-05-16T03:17:35.245Z","creation":"2026-05-16T03:13:06.04Z"},"accession":"S-EPMC12583464","cross_references":{"pubmed":["41184223"],"doi":["10.1038/s41420-025-02800-6"]}}