{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chaudhry G"],"funding":["U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)"],"pagination":["9688"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12583555"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Satellite DNA comprises ~11% of the mouse genome and is primarily located in centromeres and pericentromeres. We present comprehensive genomic and epigenomic maps of these regions utilizing Hifiasm assemblies, CUT&RUN-seq, DNA methylation analysis, and RNA-seq alongside recent mouse telomere-to-telomere assembly drafts. We show that 120-mer Minor satellites (MiSats) occupy core centromeres, while MiSat length variants localize at centromere-pericentric junctions. Pericentromeres contain mostly homogeneous Major satellites (MaSats), with divergent MaSats concentrated near pericentric non-satellite repeat islands and pericentric-chromosomal junctions. Most centromeres contain higher-order repeats (HORs), with shorter HORs more common. Centromeres are hypomethylated compared to pericentromere"],"journal":["Nature communications"],"pubmed_title":["Genomic and epigenomic maps of mouse centromeres and pericentromeres."],"pmcid":["PMC12583555"],"funding_grant_id":["1R35GM147558-01"],"pubmed_authors":["Bahl S","Chen J","Snipes L","Lin X","Packiaraj J","Thakur J","Chaudhry G"],"additional_accession":[]},"is_claimable":false,"name":"Genomic and epigenomic maps of mouse centromeres and pericentromeres.","description":"Satellite DNA comprises ~11% of the mouse genome and is primarily located in centromeres and pericentromeres. We present comprehensive genomic and epigenomic maps of these regions utilizing Hifiasm assemblies, CUT&RUN-seq, DNA methylation analysis, and RNA-seq alongside recent mouse telomere-to-telomere assembly drafts. We show that 120-mer Minor satellites (MiSats) occupy core centromeres, while MiSat length variants localize at centromere-pericentric junctions. Pericentromeres contain mostly homogeneous Major satellites (MaSats), with divergent MaSats concentrated near pericentric non-satellite repeat islands and pericentric-chromosomal junctions. Most centromeres contain higher-order repeats (HORs), with shorter HORs more common. Centromeres are hypomethylated compared to pericentromere","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T11:47:00.053Z","creation":"2026-05-16T03:12:52.713Z"},"accession":"S-EPMC12583555","cross_references":{"pubmed":["41184258"],"doi":["10.1038/s41467-025-64689-0"]}}