{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["83(1)"],"submitter":["GBD 2021 US CNS Cancer Collaborators"],"pubmed_abstract":["<h4>Importance</h4>Primary brain and central nervous system cancer (collectively referred to as CNS cancer) comprises 2% of all human cancers and poses significant health and economic challenges in the United States.<h4>Objective</h4>To analyze CNS cancer burden in the US, stratified by time, location (state and division), sex, age group, and Sociodemographic Index (SDI).<h4>Design, setting, and participants</h4>This cross-sectional study involved a repeated analysis of Global Burden of Disease Study (GBD) 2021 data in 2024. Using data from 183 sources, CNS cancer metrics in the US were estimated across states and years. US CNS cancer metrics across all sexes and age groups were included in the GBD.<h4>Exposure</h4>CNS cancer diagnosis.<h4>Main outcomes and measures</h4>Overall and age-sta"],"journal":["JAMA neurology"],"pagination":["35-48"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12584065"],"repository":["biostudies-literature"],"pubmed_title":["Burden of Central Nervous System Cancer in the United States, 1990-2021."],"pmcid":["PMC12584065"],"pubmed_authors":["Gholamrezanezhad A","Yon DK","Sherchan SP","Fotouhi M","Abu-Zaid A","Bilgin GB","Fazeli P","Murray CJL","Ramasamy SK","Kalani R","Verma A","Solanki R","Mokdad AH","Azzam AY","Jalloh M","Dean FE","Kankam SB","Khosla AA","Singh JA","Ida F","Parikh RR","Schumacher AE","Elhadi M","Taiba J","Fisher JL","Puvvula J","Yunusa I","Senol YC","Deekonda S","Pestell RG","Zheng DX","Park S","Areda D","Jani CT","Bhuyan SS","Arul S","Bhardwaj PV","Prabhu D","Park KY","Bayat Tork MA","Lim SS","Simegn GL","Tanwar M","Keshwani A","Srichawla BS","Mehboob R","Naik G","Fares J","Kim MS","Natto ZS","Kazemi F","Penberthy L","Mestrovic T","Nugen F","Dai X","Shin JI","Ding X","Bardhan M","Ababneh HS","Sham S","Kim YS","Behnam B","Moon JH","Chen MX","Han HJ","Lomer NB","Orscelik A","Iwu CD","Kim YB","Amirikah MT","GBD 2021 US CNS Cancer Collaborators","Doshi OP","Chennapragada SS","Nguyen D","Sabet CJ","E'mar AR"],"additional_accession":[]},"is_claimable":false,"name":"Burden of Central Nervous System Cancer in the United States, 1990-2021.","description":"<h4>Importance</h4>Primary brain and central nervous system cancer (collectively referred to as CNS cancer) comprises 2% of all human cancers and poses significant health and economic challenges in the United States.<h4>Objective</h4>To analyze CNS cancer burden in the US, stratified by time, location (state and division), sex, age group, and Sociodemographic Index (SDI).<h4>Design, setting, and participants</h4>This cross-sectional study involved a repeated analysis of Global Burden of Disease Study (GBD) 2021 data in 2024. Using data from 183 sources, CNS cancer metrics in the US were estimated across states and years. US CNS cancer metrics across all sexes and age groups were included in the GBD.<h4>Exposure</h4>CNS cancer diagnosis.<h4>Main outcomes and measures</h4>Overall and age-sta","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T20:01:49.011Z","creation":"2026-06-04T03:12:54.623Z"},"accession":"S-EPMC12584065","cross_references":{"pubmed":["41182787"],"doi":["10.1001/jamaneurol.2025.4286"]}}