biostudies-literatureSanchez CIMinisterio de Ciencia, Innovación y Universidadese0227925https://www.ebi.ac.uk/biostudies/studies/S-EPMC12584730biostudies-literatureUnknown13(11)The filamentous fungus <i>Aspergillus fumigatus</i> is equipped with an efficient zinc uptake system that allows this fungus to survive and grow within the very zinc-limiting environment provided by the lungs of immunosuppressed patients. To deal with zinc scarcity, <i>A. fumigatus</i> deploys a homeostatic and adaptive response that enables it to scavenge for and uptake zinc from host tissues. Finally, zinc ions are distributed intracellularly and lodged in fungal proteins that require them for normal functioning. It is believed that most zinc-requiring proteins acquire zinc ions to become properly metalated by competition with cellular zinc proteins. However, certain zinc proteins may exhibit inherent thermodynamic and/or physicochemical properties that hamper them from competing for zinMicrobiology spectrumZinc-metallochaperones of <i>Aspergillus fumigatus</i> are involved in ROS production and folate biosynthesis during zinc deficiency.PMC12584730PID2019-110994RB-I00Marin LAmich JCalera JASanchez CIDiaz VAlcazar LfalseZinc-metallochaperones of <i>Aspergillus fumigatus</i> are involved in ROS production and folate biosynthesis during zinc deficiency.The filamentous fungus <i>Aspergillus fumigatus</i> is equipped with an efficient zinc uptake system that allows this fungus to survive and grow within the very zinc-limiting environment provided by the lungs of immunosuppressed patients. To deal with zinc scarcity, <i>A. fumigatus</i> deploys a homeostatic and adaptive response that enables it to scavenge for and uptake zinc from host tissues. Finally, zinc ions are distributed intracellularly and lodged in fungal proteins that require them for normal functioning. It is believed that most zinc-requiring proteins acquire zinc ions to become properly metalated by competition with cellular zinc proteins. However, certain zinc proteins may exhibit inherent thermodynamic and/or physicochemical properties that hamper them from competing for zin2025-01-01T00:00:00Z2025 Nov2026-06-05T11:59:26.854Z2026-05-16T03:13:07.668ZS-EPMC125847304098594810.1128/spectrum.02279-25