{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lukas Petrova S"],"funding":["Ministerstvo Školství, Mládeže a Tělovýchovy"],"pagination":["8023-8036"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12584748"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(24)"],"pubmed_abstract":["We report a versatile and efficient strategy for the synthesis of dual thermo- and pH-responsive polymeric nano-objects with rich morphological diversity, achieved <i>via</i> RAFT-mediated aqueous emulsion polymerization-induced self-assembly (PISA). Using a thermoresponsive poly(triethylene glycol methyl ether methacrylate) (PTEGMA) macro-chain transfer agent and a pH-sensitive diisopropylaminoethyl methacrylate (DPA) monomer, we generated PTEGMA-<i>b</i>-PDPA diblock copolymer nano-objects under conditions both below and above the LCST of PTEGMA. By systematically varying the length of the PDPA block, we accessed a wide array of morphologies-including micelles, worms, vesicles, and intricate \"octopus\"-like structures-simply by adjusting the polymerization temperature and hydrophobic bloc"],"journal":["Nanoscale advances"],"pubmed_title":["Synthesis of morphologically diverse dual thermo- and pH-responsive nano-objects &lt;i&gt;via&lt;/i&gt; RAFT-mediated emulsion PISA."],"pmcid":["PMC12584748"],"funding_grant_id":["# LM2023053","CZ.02.01.01/00/22_008/0004607"],"pubmed_authors":["Pokorny V","Hruby M","Lukas Petrova S","Pavlova E"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of morphologically diverse dual thermo- and pH-responsive nano-objects &lt;i&gt;via&lt;/i&gt; RAFT-mediated emulsion PISA.","description":"We report a versatile and efficient strategy for the synthesis of dual thermo- and pH-responsive polymeric nano-objects with rich morphological diversity, achieved <i>via</i> RAFT-mediated aqueous emulsion polymerization-induced self-assembly (PISA). Using a thermoresponsive poly(triethylene glycol methyl ether methacrylate) (PTEGMA) macro-chain transfer agent and a pH-sensitive diisopropylaminoethyl methacrylate (DPA) monomer, we generated PTEGMA-<i>b</i>-PDPA diblock copolymer nano-objects under conditions both below and above the LCST of PTEGMA. By systematically varying the length of the PDPA block, we accessed a wide array of morphologies-including micelles, worms, vesicles, and intricate \"octopus\"-like structures-simply by adjusting the polymerization temperature and hydrophobic bloc","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-05T21:58:12.027Z","creation":"2026-05-22T03:16:02.589Z"},"accession":"S-EPMC12584748","cross_references":{"pubmed":["41195310"],"doi":["10.1039/d5na00779h"]}}