biostudies-literatureLukas Petrova SMinisterstvo Školství, Mládeže a Tělovýchovy8023-8036https://www.ebi.ac.uk/biostudies/studies/S-EPMC12584748biostudies-literatureUnknown7(24)We report a versatile and efficient strategy for the synthesis of dual thermo- and pH-responsive polymeric nano-objects with rich morphological diversity, achieved <i>via</i> RAFT-mediated aqueous emulsion polymerization-induced self-assembly (PISA). Using a thermoresponsive poly(triethylene glycol methyl ether methacrylate) (PTEGMA) macro-chain transfer agent and a pH-sensitive diisopropylaminoethyl methacrylate (DPA) monomer, we generated PTEGMA-<i>b</i>-PDPA diblock copolymer nano-objects under conditions both below and above the LCST of PTEGMA. By systematically varying the length of the PDPA block, we accessed a wide array of morphologies-including micelles, worms, vesicles, and intricate "octopus"-like structures-simply by adjusting the polymerization temperature and hydrophobic blocNanoscale advancesSynthesis of morphologically diverse dual thermo- and pH-responsive nano-objects &lt;i&gt;via&lt;/i&gt; RAFT-mediated emulsion PISA.PMC12584748# LM2023053CZ.02.01.01/00/22_008/0004607Pokorny VHruby MLukas Petrova SPavlova EfalseSynthesis of morphologically diverse dual thermo- and pH-responsive nano-objects &lt;i&gt;via&lt;/i&gt; RAFT-mediated emulsion PISA.We report a versatile and efficient strategy for the synthesis of dual thermo- and pH-responsive polymeric nano-objects with rich morphological diversity, achieved <i>via</i> RAFT-mediated aqueous emulsion polymerization-induced self-assembly (PISA). Using a thermoresponsive poly(triethylene glycol methyl ether methacrylate) (PTEGMA) macro-chain transfer agent and a pH-sensitive diisopropylaminoethyl methacrylate (DPA) monomer, we generated PTEGMA-<i>b</i>-PDPA diblock copolymer nano-objects under conditions both below and above the LCST of PTEGMA. By systematically varying the length of the PDPA block, we accessed a wide array of morphologies-including micelles, worms, vesicles, and intricate "octopus"-like structures-simply by adjusting the polymerization temperature and hydrophobic bloc2025-01-01T00:00:00Z2025 Dec2026-06-05T21:58:12.027Z2026-05-22T03:16:02.589ZS-EPMC125847484119531010.1039/d5na00779h