{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Deng WQ"],"funding":["Canada Research Chair in Translational Addiction Research","Peter Boris Centre for Addictions Research","Medical Research Council (MRC) Integrative Epidemiology Unit at the University of Bristol","UK Medical Research Council and Wellcome","Wellcome Trust"],"pagination":["2559-2572"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12586799"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["120(12)"],"pubmed_abstract":["<h4>Background and aims</h4>Recent large studies have established the genetic basis of several conceptually linked phenotypes of externalizing. Polygenic risk scores (PRSs) for these constructs are associated with a range of substance use and mental disorder phenotypes but have not been examined with both pharmacological and non-pharmacological addictive behaviors, or across a developmental window. This study identified biological pathways responsible for observed associations between PRSs and addiction phenotypes.<h4>Design, setting, participants</h4>We selected genome-wide association studies of 22 phenotypes, including substance use, general factors of externalizing and addiction, impulsivity and psychiatric conditions. Using summary statistics, we constructed PRSs in the offspring from"],"journal":["Addiction (Abingdon, England)"],"pubmed_title":["Externalizing as a common genetic influence for a broad spectrum of substance use and behavioral conditions: A developmental perspective from the Avon Longitudinal Study of Parents and Children."],"pmcid":["PMC12586799"],"funding_grant_id":["217065/Z/19/Z","CRC-2020-00179","MC_UU_00032/07"],"pubmed_authors":["Belisario K","Doggett A","Munafo MR","Pare G","MacKillop J","Pigeyre M","Deng WQ"],"additional_accession":[]},"is_claimable":false,"name":"Externalizing as a common genetic influence for a broad spectrum of substance use and behavioral conditions: A developmental perspective from the Avon Longitudinal Study of Parents and Children.","description":"<h4>Background and aims</h4>Recent large studies have established the genetic basis of several conceptually linked phenotypes of externalizing. Polygenic risk scores (PRSs) for these constructs are associated with a range of substance use and mental disorder phenotypes but have not been examined with both pharmacological and non-pharmacological addictive behaviors, or across a developmental window. This study identified biological pathways responsible for observed associations between PRSs and addiction phenotypes.<h4>Design, setting, participants</h4>We selected genome-wide association studies of 22 phenotypes, including substance use, general factors of externalizing and addiction, impulsivity and psychiatric conditions. Using summary statistics, we constructed PRSs in the offspring from","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T15:30:29.364Z","creation":"2026-06-01T03:11:05.693Z"},"accession":"S-EPMC12586799","cross_references":{"pubmed":["40767372"],"doi":["10.1111/add.70163"]}}