biostudies-literatureUnknown15(11)Wuermli ALEGO Foundation<h4>Purpose</h4>As of 2024, 123.2 million people had been forcibly displaced as a result of persecution, armed conflict or climate-related catastrophes, and these numbers are predicted to rise. There is a growing awareness of possible intergenerational effects of trauma on life-course health and well-being, however few studies have followed individuals longitudinally starting prenatally. This paper describes the first large prenatal birth cohort study in a refugee context in a lower middle-income country. This study aims to investigate the potential lifespan health and developmental implications of being born into a protracted humanitarian context, and what factors can buffer from the adversity posed by conflict and displacement.<h4>Participants</h4>We outline our approach of recruiting, cBMJ opene099052https://www.ebi.ac.uk/biostudies/studies/S-EPMC12588014biostudies-literatureCohort profile: a prenatal birth cohort study of intergenerational risk and resilience after conflict and forced displacement.PMC12588014Ahamed MSRahim AKAkhter RMRaqib RYoshikawa HHoraira MAHastings PDRatul TIElahi MRahman MSHiott MCHamadani JAlam RBUgarte EGladstone MMichael DTofail FSanin KIRoy BRHossain EHaseen SHAyrin TKWuermli ADutta GKfalseCohort profile: a prenatal birth cohort study of intergenerational risk and resilience after conflict and forced displacement.<h4>Purpose</h4>As of 2024, 123.2 million people had been forcibly displaced as a result of persecution, armed conflict or climate-related catastrophes, and these numbers are predicted to rise. There is a growing awareness of possible intergenerational effects of trauma on life-course health and well-being, however few studies have followed individuals longitudinally starting prenatally. This paper describes the first large prenatal birth cohort study in a refugee context in a lower middle-income country. This study aims to investigate the potential lifespan health and developmental implications of being born into a protracted humanitarian context, and what factors can buffer from the adversity posed by conflict and displacement.<h4>Participants</h4>We outline our approach of recruiting, c2025-01-01T00:00:00Z2025 Nov2026-06-05T17:56:50.534Z2026-05-19T03:11:53.103ZS-EPMC125880144124833810.1136/bmjopen-2025-099052