{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["33(4)"],"submitter":["Suuring M"],"pubmed_abstract":["Cell therapy is a promising approach for inducing tolerance and thus reducing the use of immunosuppressive drugs in several immune-mediated conditions. Tolerogenic dendritic cells (tolDCs) regulate antigen-specific tolerance and control the immune response, making them an interesting candidate for cell therapy. Over the last years, different human tolDCs have been generated <i>ex vivo</i>, each with specific phenotypic and functional characteristics. This study aims to highlight the impact of the manufacturing process on tolDC function. For that, two well-known tolDCs, autologous tolerogenic dendritic cells (ATDCs) and interleukin (IL)-10-induced dendritic cells (DC-10s), were compared based on their phenotype, metabolic secretion, transcriptomic profile, and their modulatory function. Our"],"journal":["Molecular therapy. Methods & clinical development"],"pagination":["101605"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12589953"],"repository":["biostudies-literature"],"pubmed_title":["Protocol of generation of tolerogenic dendritic cells affects their transcriptional and metabolic profiles leading to specific tolerogenic functions."],"pmcid":["PMC12589953"],"pubmed_authors":["Lavercan D","Chiffoleau E","Cloteau C","Croyal M","Rouel M","Suuring M","Gregori S","Raux A","Delhaye T","Royer AL","Santoni de Sio F","Rondeau D","Moreau A","Amodio G"],"additional_accession":[]},"is_claimable":false,"name":"Protocol of generation of tolerogenic dendritic cells affects their transcriptional and metabolic profiles leading to specific tolerogenic functions.","description":"Cell therapy is a promising approach for inducing tolerance and thus reducing the use of immunosuppressive drugs in several immune-mediated conditions. Tolerogenic dendritic cells (tolDCs) regulate antigen-specific tolerance and control the immune response, making them an interesting candidate for cell therapy. Over the last years, different human tolDCs have been generated <i>ex vivo</i>, each with specific phenotypic and functional characteristics. This study aims to highlight the impact of the manufacturing process on tolDC function. For that, two well-known tolDCs, autologous tolerogenic dendritic cells (ATDCs) and interleukin (IL)-10-induced dendritic cells (DC-10s), were compared based on their phenotype, metabolic secretion, transcriptomic profile, and their modulatory function. Our","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-05T14:44:45.623Z","creation":"2026-05-18T03:08:20.463Z"},"accession":"S-EPMC12589953","cross_references":{"pubmed":["41210169"],"doi":["10.1016/j.omtm.2025.101605"]}}