biostudies-literatureUnknown4(11 Pt 1)Ozaki S<h4>Background</h4>Introduced in 2007, the Ozaki procedure-templated cusp replacement with autologous pericardium-is a new option for treating aortic valve disease. Mid-term outcomes and valve performance have not yet been reported.<h4>Objectives</h4>This study assesses longitudinal hemodynamics, left ventricular reverse remodeling, reoperation, and survival in the original Ozaki cohort.<h4>Methods</h4>1,196 patients underwent Ozaki procedures (60% male, age 11-90 years) at Toho University Ohashi Medical Center from April 2007 to May 2021: 2.4% had infective endocarditis, 27% had bicuspid valves, 54% had aortic stenosis, 24% had aortic regurgitation, 7.3% had mixed lesions, and 46% underwent concomitant procedures. Clinical outcomes, echocardiograms, and follow-up data (50% followed >3.2 yJACC. Advances102156https://www.ebi.ac.uk/biostudies/studies/S-EPMC12589979biostudies-literatureMid-Term Experience With 1,196 Ozaki Procedures.PMC12589979Takatoo MShimura SGoda MOzaki SHoshino YHayama HRajeswaran JSvensson LGKiyohara NUnai SPettersson GBFrankel WCHarb SCBlackstone EHfalseMid-Term Experience With 1,196 Ozaki Procedures.<h4>Background</h4>Introduced in 2007, the Ozaki procedure-templated cusp replacement with autologous pericardium-is a new option for treating aortic valve disease. Mid-term outcomes and valve performance have not yet been reported.<h4>Objectives</h4>This study assesses longitudinal hemodynamics, left ventricular reverse remodeling, reoperation, and survival in the original Ozaki cohort.<h4>Methods</h4>1,196 patients underwent Ozaki procedures (60% male, age 11-90 years) at Toho University Ohashi Medical Center from April 2007 to May 2021: 2.4% had infective endocarditis, 27% had bicuspid valves, 54% had aortic stenosis, 24% had aortic regurgitation, 7.3% had mixed lesions, and 46% underwent concomitant procedures. Clinical outcomes, echocardiograms, and follow-up data (50% followed >3.2 y2025-01-01T00:00:00Z2025 Nov2026-07-15T11:16:14.913Z2026-07-04T03:11:48.365ZS-EPMC125899794112498410.1016/j.jacadv.2025.102156