{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["28(11)"],"submitter":["Ma W"],"pubmed_abstract":["The kinase thousand and one amino acid kinase 2 (TAOK2) regulates dendritic architecture and synaptic plasticity and is implicated in neurodevelopmental and neuropsychiatric disorders, including autism and schizophrenia. Here, we investigated TAOK2 function by creating an <i>Emx1-Cre</i>-driven, excitatory-neuron-specific conditional <i>Taok2</i> knockout (<i>Taok2</i> cKO) mouse line. Pathway profiling in <i>Taok2</i> cKO primary cortical neurons revealed impaired extracellular regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) and calcium signaling after AMPA, BDNF, or bicuculline stimulation. These results were validated by reduced p-ERK1/2 protein levels and decreased calcium flux. Cultured <i>Taok2</i> cKO neurons displayed reduced synaptic density and connectivity. Single"],"journal":["iScience"],"pagination":["113712"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12590003"],"repository":["biostudies-literature"],"pubmed_title":["TAOK2 controls synaptic plasticity and anxiety via ERK and calcium signaling."],"pmcid":["PMC12590003"],"pubmed_authors":["Volkmann P","Rossner MJ","Jensen N","Scheuss V","Stephan M","Dehne K","Ma X","Kannaiyan N","Wehr MC","Brankatschk B","Warnhoff I","Ma W"],"additional_accession":[]},"is_claimable":false,"name":"TAOK2 controls synaptic plasticity and anxiety via ERK and calcium signaling.","description":"The kinase thousand and one amino acid kinase 2 (TAOK2) regulates dendritic architecture and synaptic plasticity and is implicated in neurodevelopmental and neuropsychiatric disorders, including autism and schizophrenia. Here, we investigated TAOK2 function by creating an <i>Emx1-Cre</i>-driven, excitatory-neuron-specific conditional <i>Taok2</i> knockout (<i>Taok2</i> cKO) mouse line. Pathway profiling in <i>Taok2</i> cKO primary cortical neurons revealed impaired extracellular regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) and calcium signaling after AMPA, BDNF, or bicuculline stimulation. These results were validated by reduced p-ERK1/2 protein levels and decreased calcium flux. Cultured <i>Taok2</i> cKO neurons displayed reduced synaptic density and connectivity. Single","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T13:45:42.05Z","creation":"2026-06-05T03:06:56.531Z"},"accession":"S-EPMC12590003","cross_references":{"pubmed":["41210984"],"doi":["10.1016/j.isci.2025.113712"]}}