{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["56"],"submitter":["Sun S"],"pubmed_abstract":["Chemoresistance and immunosuppression serve as major obstacles that compromise the therapeutic efficacy of chemoimmunotherapy. Herein, we reported a novel chemoimmunotherapy strategy employing metal fluoride to modulate Wnt/β-catenin signaling, effectively remodeling treatment resistance and eliciting pyroptosis-mediated immune activation. Through systematic screening of various nonmetallic anions (F-, Cl-, Br-, I-, CO3 2-, PO4 3-, S2-, and Se2-), we identified F- as an effective inhibitor of β-catenin expression and tumor stemness. The synergistic combination of F- with chemotherapy significantly attenuated tumor stemness and enhanced treatment efficacy. We f"],"journal":["Bioactive materials"],"pagination":["248-259"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12590230"],"repository":["biostudies-literature"],"pubmed_title":["Metal fluoride nanoregulators reverse therapeutic resistance via stemness remodeling to trigger pyroptosis for chemoimmunotherapy."],"pmcid":["PMC12590230"],"pubmed_authors":["Yang N","Sun S","Wang D","Nie J","Cheng L","Zhang L","Sun X","Jin Y"],"additional_accession":[]},"is_claimable":false,"name":"Metal fluoride nanoregulators reverse therapeutic resistance via stemness remodeling to trigger pyroptosis for chemoimmunotherapy.","description":"Chemoresistance and immunosuppression serve as major obstacles that compromise the therapeutic efficacy of chemoimmunotherapy. Herein, we reported a novel chemoimmunotherapy strategy employing metal fluoride to modulate Wnt/β-catenin signaling, effectively remodeling treatment resistance and eliciting pyroptosis-mediated immune activation. Through systematic screening of various nonmetallic anions (F-, Cl-, Br-, I-, CO3 2-, PO4 3-, S2-, and Se2-), we identified F- as an effective inhibitor of β-catenin expression and tumor stemness. The synergistic combination of F- with chemotherapy significantly attenuated tumor stemness and enhanced treatment efficacy. We f","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-06-05T14:44:40.091Z","creation":"2026-05-18T03:08:19.496Z"},"accession":"S-EPMC12590230","cross_references":{"pubmed":["41211577"],"doi":["10.1016/j.bioactmat.2025.10.011"]}}