biostudies-literatureUnknown5(6)Knochel TDIn a rapidly evolving Generative Artificial Intelligence (GenAI) landscape, researchers, policymakers, and publishers have to continuously redefine responsible research practices. To ensure guidance of GenAI use in research, core principles that remain stable despite technological advancement are needed. This article defines a list of principles guiding the responsible use of GenAI in research, regardless of use case and GenAI technology employed. To define this framework, we conducted an anonymised Delphi consensus procedure comprising a panel of 16 international and multidisciplinary experts in AI, social sciences, law, ethics, and scientific publishing. After three rounds of independent rating and feedback, the panel reached consensus on eight sequentially ordered principles required foAI and ethics6371-6377https://www.ebi.ac.uk/biostudies/studies/S-EPMC12592249biostudies-literatureCore principles of responsible generative AI usage in research.PMC12592249Kovacs MYang YFLiu MPeeters AKnochel TDHeyselaar EAczel BLin ZAl-Hoorie AHAcar OAHosseini MVranka MABuehler FElsherif MMGiannini AYamada YAkil AMIlangovan VRavenzwaaij DVSchweizer KJfalseCore principles of responsible generative AI usage in research.In a rapidly evolving Generative Artificial Intelligence (GenAI) landscape, researchers, policymakers, and publishers have to continuously redefine responsible research practices. To ensure guidance of GenAI use in research, core principles that remain stable despite technological advancement are needed. This article defines a list of principles guiding the responsible use of GenAI in research, regardless of use case and GenAI technology employed. To define this framework, we conducted an anonymised Delphi consensus procedure comprising a panel of 16 international and multidisciplinary experts in AI, social sciences, law, ethics, and scientific publishing. After three rounds of independent rating and feedback, the panel reached consensus on eight sequentially ordered principles required fo2025-01-01T00:00:00Z20252026-06-05T14:46:25.955Z2026-05-18T03:08:34.856ZS-EPMC125922494120932910.1007/s43681-025-00768-8