biostudies-literatureUnknown37(44)Wu QIsrael Science FoundationCouncil for Higher Education, IsraelTechnion's president grantNeubauer Family FoundationConventional suturing and stapling cause additional trauma, pain, and cost for patients. As alternatives, existing bioadhesives suffer from imprecise fabrication, limited wet tissue adhesion, and insufficient biological functionalities for effective wound management. This work proposes biomimetic hydrogel bioadhesives composed of modified natural tannic acid (TA), hyperbranched polylysine (HPL), and acrylic acid (AA), abbreviated PTLAs, to offer solutions for tissue adhesion under challenging environments (underwater, body fluids, cold, pressure), and for enhanced healthcare. These PTLAs are fabricated via 3D printing, enabling the precise and controlled production of bioadhesives that are customized in a personalized manner with great reproducibility. Inspired by molluscs, developed PTLAsAdvanced materials (Deerfield Beach, Fla.)e2502850https://www.ebi.ac.uk/biostudies/studies/S-EPMC12592912biostudies-literatureBiomimetic 3D-Printed Adaptive Hydrogel Bioadhesives Featuring Superior Infection Resistance for Challenging Tissue Adhesion, Hemostasis, and Healthcare.PMC12592912Nassar-Marjiya EWu QChauhan MKhamaisi BFarah SfalseBiomimetic 3D-Printed Adaptive Hydrogel Bioadhesives Featuring Superior Infection Resistance for Challenging Tissue Adhesion, Hemostasis, and Healthcare.Conventional suturing and stapling cause additional trauma, pain, and cost for patients. As alternatives, existing bioadhesives suffer from imprecise fabrication, limited wet tissue adhesion, and insufficient biological functionalities for effective wound management. This work proposes biomimetic hydrogel bioadhesives composed of modified natural tannic acid (TA), hyperbranched polylysine (HPL), and acrylic acid (AA), abbreviated PTLAs, to offer solutions for tissue adhesion under challenging environments (underwater, body fluids, cold, pressure), and for enhanced healthcare. These PTLAs are fabricated via 3D printing, enabling the precise and controlled production of bioadhesives that are customized in a personalized manner with great reproducibility. Inspired by molluscs, developed PTLAs2025-01-01T00:00:00Z2025 Nov2026-06-05T13:54:26.17Z2026-05-17T03:12:46.722ZS-EPMC125929124069329410.1002/adma.202502850