{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(48)"],"submitter":["Cobb JRE"],"pubmed_abstract":["Cation-switchable catalysis is a promising strategy for modulating reaction rates or selectivity using external stimuli, with potential applications including polymer synthesis and tandem catalysis. This study establishes a deeper understanding of the mechanistic origins of cation rate promotion in systems where a hemilabile crown ether affixed to the catalyst serves as a cation receptor site, which in turn enables reactivity extensions of this platform to introduce cation-switchable alkene hydrogenation. The mechanistic study hinges on the synthesis of two previously unreported iridium(iii) complexes, bearing either bis(2-methoxyethyl)amine or diethylamine groups, which could be compared in catalysis with and without cation promoters. Only the catalyst containing a crown ether exhibits sw"],"journal":["Chemical science"],"pagination":["23330-23341"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12593864"],"repository":["biostudies-literature"],"pubmed_title":["Cation-switchable transposition and hydrogenation of alkenes <i>via</i> interconnected reaction mechanisms."],"pmcid":["PMC12593864"],"pubmed_authors":["Yoo C","Bhattacharya S","Miller AJM","Cobb JRE","Dodge HM","Chen CH","Perez Galarza ED","Stuart ZE"],"additional_accession":[]},"is_claimable":false,"name":"Cation-switchable transposition and hydrogenation of alkenes <i>via</i> interconnected reaction mechanisms.","description":"Cation-switchable catalysis is a promising strategy for modulating reaction rates or selectivity using external stimuli, with potential applications including polymer synthesis and tandem catalysis. This study establishes a deeper understanding of the mechanistic origins of cation rate promotion in systems where a hemilabile crown ether affixed to the catalyst serves as a cation receptor site, which in turn enables reactivity extensions of this platform to introduce cation-switchable alkene hydrogenation. The mechanistic study hinges on the synthesis of two previously unreported iridium(iii) complexes, bearing either bis(2-methoxyethyl)amine or diethylamine groups, which could be compared in catalysis with and without cation promoters. Only the catalyst containing a crown ether exhibits sw","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-07-15T06:43:40.167Z","creation":"2026-06-30T03:22:52.383Z"},"accession":"S-EPMC12593864","cross_references":{"pubmed":["41210286"],"doi":["10.1039/d5sc06143a"]}}