biostudies-literatureUnknown15(1)Khalifa MThis study explores the novel application of a pyridine-thiazole hybrid adsorbent, MPHT 4, for the efficient removal of methylene blue (MB) from contaminated water. The adsorbent was synthesized via a high-yield route and characterized using ¹H/¹³C NMR, IR spectroscopy, HRESI-MS, elemental analysis, SEM, and BET surface area measurements. SEM revealed a homogeneous morphology with low porosity, while BET analysis indicated a surface area of 68.83 m²/g and a total pore volume of 0.113 cm³/g, classifying the material as a Type IV isotherm with micropores. The adsorption efficiency of MPHT 4 was systematically evaluated, achieving 86.7% removal of 25 ppm MB at pH 7 with a dosage of 1.0 g/L within 60 min. Kinetic studies confirmed a pseudo-second-order mechanisScientific reports39016https://www.ebi.ac.uk/biostudies/studies/S-EPMC12595033biostudies-literatureDesign and evaluation of a novel pyridine-thiazole hybrid adsorbent as high-capacity adsorbent for methylene blue removal from water.PMC12595033Shokr IElakraa SAmmar SElsaka EElsobhy EAyman RKhalifa OKhalifa MFarag DSalama EElmasry YMaklad FGaber RGhallab NAbdelkader AAli SReda AMohamed WfalseDesign and evaluation of a novel pyridine-thiazole hybrid adsorbent as high-capacity adsorbent for methylene blue removal from water.This study explores the novel application of a pyridine-thiazole hybrid adsorbent, MPHT 4, for the efficient removal of methylene blue (MB) from contaminated water. The adsorbent was synthesized via a high-yield route and characterized using ¹H/¹³C NMR, IR spectroscopy, HRESI-MS, elemental analysis, SEM, and BET surface area measurements. SEM revealed a homogeneous morphology with low porosity, while BET analysis indicated a surface area of 68.83 m²/g and a total pore volume of 0.113 cm³/g, classifying the material as a Type IV isotherm with micropores. The adsorption efficiency of MPHT 4 was systematically evaluated, achieving 86.7% removal of 25 ppm MB at pH 7 with a dosage of 1.0 g/L within 60 min. Kinetic studies confirmed a pseudo-second-order mechanis2025-01-01T00:00:00Z2025 Nov2026-06-06T13:58:28.031Z2026-05-31T03:10:17.42ZS-EPMC125950334120369410.1038/s41598-025-19531-4