{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Huang H"],"pubmed_abstract":["The study of soft, amorphous fascia has been constrained by definitional ambiguities regarding its fine structure, constituent and precise function. Here, a previously unrecognized CD34<sup>+</sup> membranous cell (CMC) population was identified by single-cell RNA sequencing, which displayed a distinct spatial distribution in UMAP coordinates in the subcutaneous fascia of rat abdominal midline. Constituting one of the predominant cell populations in the fascia, CMCs were further validated morphologically in situ and in vitro. They exhibited lamina shapes and distributed alternating with the collagen bundles. Equipped with mechanosensors (integrins, cadherins, PIEZOs), CMCs are intricately interwoven with matrix fibers, forming the tensile mechanical apparatuses in the fascia. Enriched with"],"journal":["Scientific reports"],"pagination":["39032"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12595078"],"repository":["biostudies-literature"],"pubmed_title":["Laminar CD34+ membranous cells with mechanosensitive properties in subcutaneous fascia of the abdominal midline."],"pmcid":["PMC12595078"],"pubmed_authors":["Mei L","Lu L","Dai M","Chen Q","Zhang Z","Huang H","Yang M","Fan L","Yang T","Yue J"],"additional_accession":[]},"is_claimable":false,"name":"Laminar CD34+ membranous cells with mechanosensitive properties in subcutaneous fascia of the abdominal midline.","description":"The study of soft, amorphous fascia has been constrained by definitional ambiguities regarding its fine structure, constituent and precise function. Here, a previously unrecognized CD34<sup>+</sup> membranous cell (CMC) population was identified by single-cell RNA sequencing, which displayed a distinct spatial distribution in UMAP coordinates in the subcutaneous fascia of rat abdominal midline. Constituting one of the predominant cell populations in the fascia, CMCs were further validated morphologically in situ and in vitro. They exhibited lamina shapes and distributed alternating with the collagen bundles. Equipped with mechanosensors (integrins, cadherins, PIEZOs), CMCs are intricately interwoven with matrix fibers, forming the tensile mechanical apparatuses in the fascia. Enriched with","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-06T15:33:47.654Z","creation":"2026-06-02T03:08:41.544Z"},"accession":"S-EPMC12595078","cross_references":{"pubmed":["41203776"],"doi":["10.1038/s41598-025-25651-8"]}}