{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang M"],"funding":["Shenzhen Science and Technology Innovation Program","Hebei Provincial Natural Science Foundation","Basic and Applied Basic Research Foundation of Guangdong Province","National Natural Science Foundation of China"],"pagination":["105968"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12595282"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["121"],"pubmed_abstract":["<h4>Background</h4>Unexplained miscarriage (UM) occurs frequently and significantly limits global human reproduction. However, till now, whether environment-gene interactions might interactively regulate UM has not been well characterised.<h4>Methods</h4>We combined epidemiological study using a UM case-control group and in vitro functional assays using mouse model and human trophoblast HTR-8/SVneo cells. The interactions between environmental exposure to Bisphenol F (BPF) and genetic variation in TLR4 rs4986790 (A896G) were explored. Trophoblast cell migration and invasion (key functions for healthy pregnancy), the interactions between TLR4 variants and β2GPI (β-2 glycoprotein I, an inflammatory mediator), and the downstream signalling molecules MMP9 and RAC1 were investigated.<h4>Finding"],"journal":["EBioMedicine"],"pubmed_title":["Interactive effects of Bisphenol F exposure and TLR4 rs4986790 on unexplained miscarriage."],"pmcid":["PMC12595282"],"funding_grant_id":["JCYJ20220818103607015","B2024201087","JCYJ20220530144403008","2023B1515120054","JCYJ20240813180400002","JCYJ20230807111401002","JCYJ20241202152800001","82373602","2023A1515110497"],"pubmed_authors":["Wu L","Zhang H","Lin Y","Fan Q","Cheng W","Sun Y","Wang M","Zhang Z","Huang W","Guo G","Huang X","Chen W","Xing S","Zhao D","Wang Y","Yue X"],"additional_accession":[]},"is_claimable":false,"name":"Interactive effects of Bisphenol F exposure and TLR4 rs4986790 on unexplained miscarriage.","description":"<h4>Background</h4>Unexplained miscarriage (UM) occurs frequently and significantly limits global human reproduction. However, till now, whether environment-gene interactions might interactively regulate UM has not been well characterised.<h4>Methods</h4>We combined epidemiological study using a UM case-control group and in vitro functional assays using mouse model and human trophoblast HTR-8/SVneo cells. The interactions between environmental exposure to Bisphenol F (BPF) and genetic variation in TLR4 rs4986790 (A896G) were explored. Trophoblast cell migration and invasion (key functions for healthy pregnancy), the interactions between TLR4 variants and β2GPI (β-2 glycoprotein I, an inflammatory mediator), and the downstream signalling molecules MMP9 and RAC1 were investigated.<h4>Finding","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T14:50:04.488Z","creation":"2026-05-18T03:08:34.368Z"},"accession":"S-EPMC12595282","cross_references":{"pubmed":["41138667"],"doi":["10.1016/j.ebiom.2025.105968"]}}