{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alves T"],"funding":["HHS | NIH | National Institute of Dental and Craniofacial Research (NIDR)","NIDCR NIH HHS","NCATS NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","HHS | NIH | National Center for Advancing Translational Sciences (NCATS)","HHS | NIH | National Institute of Allergy and Infectious Diseases","HHS | NIH | NCI | Division of Cancer Prevention, National Cancer Institute (DCP, NCI)","HHS | NIH | National Center for Advancing Translational Sciences","HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID)","HHS | NIH | NCI | Division of Cancer Prevention, National Cancer Institute","HHS | NIH | National Heart, Lung, and Blood Institute","NCI NIH HHS","HHS | NIH | National Institute of Dental and Craniofacial Research"],"pagination":["e2507092122"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12595481"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["122(44)"],"pubmed_abstract":["Inflammasome initiates inflammation via the maturation of interleukin-1 beta (IL-1β). Periodontitis is a prevalent, male-biased disease characterized by inflammation-driven bone loss, yet the mechanism(s) of this sex bias is unknown. This study explored whether enhanced inflammasome represents a causal mechanism for this bias. Analyses of three separate human studies (>6,200 samples) show that males have significantly higher IL-1β in the gingival crevicular fluid than females during health and periodontitis. This pattern is experimentally reproduced with different versions of the ligature-induced periodontitis mouse model where males show greater IL-1β secretion than females. The inflammasome drives bone resorption in males but not females as revealed by analyses of inflammasome gene-delet"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Inflammasome targeting for periodontitis prevention is sex dependent."],"pmcid":["PMC12595481"],"funding_grant_id":["DE029625","R21 DE029625","K01 DE027087","R01 DE032830","R35 CA232109","U19 AI067798","HHSN268201700004I","UL1TR002489-03S2","DE032830","R37 AI029564","R01 AI029564","R01 AI158314","R01 DE029200","HHSN268201700002I","R01 AI153265","AI029564","P30 CA016086","R00 DE023584","HHSN268201700002C","HHSN268201700004C","AI153265","DE0234804","AI158314","AI067798","UL1 TR002489","UL1TR002489","HHSN268201700003I","HHSN268201700005I","HHSN268201700001I","HHSN268201700005C","R56 AI029564","HHSN268201700001C","HHSN268201700003C","R56 AI158314","DE027087","CA232109","DE029200"],"pubmed_authors":["Swanson KV","Ting JPY","Preisser JS","Alves T","Gill HS","Preisser H","Lietzan AD","Zhang S","Divaris K","Brickey WJ","Santos PCP","Wrobel JA","Webster-Cyriaque J","Chang J","Seaman WT","Freire M","Pirih FQ","Min HY","Beck J","Syed M","Susin C","Vias NP","Hu D","Morelli T","Marchesan JT","Moss K","Girnary MS","Styner M","Makhanova N"],"additional_accession":[]},"is_claimable":false,"name":"Inflammasome targeting for periodontitis prevention is sex dependent.","description":"Inflammasome initiates inflammation via the maturation of interleukin-1 beta (IL-1β). Periodontitis is a prevalent, male-biased disease characterized by inflammation-driven bone loss, yet the mechanism(s) of this sex bias is unknown. This study explored whether enhanced inflammasome represents a causal mechanism for this bias. Analyses of three separate human studies (>6,200 samples) show that males have significantly higher IL-1β in the gingival crevicular fluid than females during health and periodontitis. This pattern is experimentally reproduced with different versions of the ligature-induced periodontitis mouse model where males show greater IL-1β secretion than females. The inflammasome drives bone resorption in males but not females as revealed by analyses of inflammasome gene-delet","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-06T01:28:42.71Z","creation":"2026-05-24T03:11:37.054Z"},"accession":"S-EPMC12595481","cross_references":{"pubmed":["41144672"],"doi":["10.1073/pnas.2507092122"]}}