{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(1)"],"submitter":["Liang Y"],"pubmed_abstract":["To investigate the causal relationship between two adverse reproductive outcomes (male infertility and spontaneous abortion) and COVID-19 infection using Mendelian randomization (MR) analysis. A two-sample MR study was conducted to examine potential causal links between COVID-19 infection severity and reproductive outcomes, using large-scale genome-wide association study (GWAS) summary statistics from European-ancestry populations. GWAS summary statistics were analyzed for COVID-19 phenotypes (infection: <i>n</i> = 1,683,769; hospitalized: <i>n</i> = 1,557,411; very severe respiratory-confirmed: <i>n</i> = 1,388,342; critical illness: <i>n</i> = 10,056) and reproductive outcomes (spontaneous abortion: <i>n</i> = 98,453; male infertility: <i>n</i> = 73,479). Causal estimates were calculated"],"journal":["Open life sciences"],"pagination":["20251188"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12596030"],"repository":["biostudies-literature"],"pubmed_title":["Can coronavirus disease 2019 affect male fertility or cause spontaneous abortion? A two-sample Mendelian randomization analysis."],"pmcid":["PMC12596030"],"pubmed_authors":["Liang Y","He X","Ma X","Liu C","Liu T","Niu X"],"additional_accession":[]},"is_claimable":false,"name":"Can coronavirus disease 2019 affect male fertility or cause spontaneous abortion? A two-sample Mendelian randomization analysis.","description":"To investigate the causal relationship between two adverse reproductive outcomes (male infertility and spontaneous abortion) and COVID-19 infection using Mendelian randomization (MR) analysis. A two-sample MR study was conducted to examine potential causal links between COVID-19 infection severity and reproductive outcomes, using large-scale genome-wide association study (GWAS) summary statistics from European-ancestry populations. GWAS summary statistics were analyzed for COVID-19 phenotypes (infection: <i>n</i> = 1,683,769; hospitalized: <i>n</i> = 1,557,411; very severe respiratory-confirmed: <i>n</i> = 1,388,342; critical illness: <i>n</i> = 10,056) and reproductive outcomes (spontaneous abortion: <i>n</i> = 98,453; male infertility: <i>n</i> = 73,479). Causal estimates were calculated","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-05T14:24:22.037Z","creation":"2026-05-17T03:12:31.94Z"},"accession":"S-EPMC12596030","cross_references":{"pubmed":["41211060"],"doi":["10.1515/biol-2025-1188"]}}