{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chalitsios CV"],"funding":["ORIP NIH HHS","GECCO: National Cancer Institute (NCI), National Institutes of Health (NIH), US Department of Health and Human Services","World Health Organization","Center for Inherited Disease Research (CIDR)","NHLBI NIH HHS","Center for Inherited Disease Research","NCI NIH HHS","NIH/NCI Cancer Center Support","NIH HHS","ORIP"],"pagination":["pkaf095"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12596107"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(6)"],"pubmed_abstract":["<h4>Background</h4>Physical activity is associated with lower colorectal cancer (CRC) risk, but its association with molecular subtypes defined by genetic and epigenetic alterations of the disease is unclear. Such information may enhance the understanding of the mechanisms related to the benefits of physical activity.<h4>Methods</h4>Pooled observational (cases: n = 5386; controls: n = 6798; studies n = 5) and genome-wide association data (cases: n = 8178; controls: n = 10 472; studies n = 5) were used. We used multivariable logistic regression models and Mendelian randomization to assess the association between physical activity and the risk of CRC subtypes defined by individual tumor markers (and marker combinations), namely microsatellite instability status, CpG island methylator phenoty"],"journal":["JNCI cancer spectrum"],"pubmed_title":["Physical activity and molecular subtypes of colorectal cancer: a pooled observational analysis and Mendelian randomization study."],"pmcid":["PMC12596107"],"funding_grant_id":["U01 CA137088","HHSN268201700006C","001","HHSN268201200008I","S10OD028685","P30 CA015704","U01 CA137088, R01 CA176272","S10 OD028685","HHSN268201700006I and HHSN268201200008I","R01 CA176272","HHSN268201200008C"],"pubmed_authors":["Qu C","Um CY","Chalitsios CV","Huang WY","Toland AE","Trinh QM","Woods MO","Berndt SI","Zaidi SH","Drew DA","Schoen RE","Guelpen BV","Phipps AI","Schmit SL","Thomas CE","Murphy N","Huyghe JR","Peters U","Gunter MJ","Buchanan DD","Hullar MAJ","Chan AT","Obon-Santacana M","Giannakis M","French AJ","Lynch BM","Steinfelder RS","Sun W","Ugai T","Pellatt AJ","Ogino S","Tsilidis KK","Gruber SB","Markozannes G","Dimou N","Harrison TA","Campbell PT","Moreno V","Cao Y","Brenner H","Hsu L","Newton CC","Aglago EK","Georgeson P","Hoffmeister M","Nowak JA","Andreson L"],"additional_accession":[]},"is_claimable":false,"name":"Physical activity and molecular subtypes of colorectal cancer: a pooled observational analysis and Mendelian randomization study.","description":"<h4>Background</h4>Physical activity is associated with lower colorectal cancer (CRC) risk, but its association with molecular subtypes defined by genetic and epigenetic alterations of the disease is unclear. Such information may enhance the understanding of the mechanisms related to the benefits of physical activity.<h4>Methods</h4>Pooled observational (cases: n = 5386; controls: n = 6798; studies n = 5) and genome-wide association data (cases: n = 8178; controls: n = 10 472; studies n = 5) were used. We used multivariable logistic regression models and Mendelian randomization to assess the association between physical activity and the risk of CRC subtypes defined by individual tumor markers (and marker combinations), namely microsatellite instability status, CpG island methylator phenoty","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-12T04:58:42.42Z","creation":"2026-06-12T03:08:10.196Z"},"accession":"S-EPMC12596107","cross_references":{"pubmed":["41031512"],"doi":["10.1093/jncics/pkaf095"]}}