biostudies-literatureUnknown10(12)Ryg U<h4>Purpose</h4>Local failure of prostate cancer after definitive radiation therapy is associated with poor prognosis. Studies on reirradiation have primarily focused on toxicity and oncologic outcome and only partially reported recurrence patterns. Investigating the recurrence pattern may help guide future therapy decisions.<h4>Methods and materials</h4>Thirty-three men with local recurrence of prostate cancer after primary definitive radiation therapy were enrolled between 2012 and 2018 (median age 69.8 years [IQR: 6.8], median prostate-specific antigen 4.1 ng/mL [IQR: 3.8]). Twenty-three patients received reirradiation with focal high dose-rate brachytherapy, and 10 received stereotactic body radiation therapy to the prostate with (8/10) or without (2/10) a simultaneous integrated boostAdvances in radiation oncology101900https://www.ebi.ac.uk/biostudies/studies/S-EPMC12596965biostudies-literatureImage-Based Recurrence Patterns After Reirradiation in Prostate Cancer with Long-Term Follow-Up.PMC12596965Lilleby WHellebust TPSeierstad THole KHRyg UNilsen LBfalseImage-Based Recurrence Patterns After Reirradiation in Prostate Cancer with Long-Term Follow-Up.<h4>Purpose</h4>Local failure of prostate cancer after definitive radiation therapy is associated with poor prognosis. Studies on reirradiation have primarily focused on toxicity and oncologic outcome and only partially reported recurrence patterns. Investigating the recurrence pattern may help guide future therapy decisions.<h4>Methods and materials</h4>Thirty-three men with local recurrence of prostate cancer after primary definitive radiation therapy were enrolled between 2012 and 2018 (median age 69.8 years [IQR: 6.8], median prostate-specific antigen 4.1 ng/mL [IQR: 3.8]). Twenty-three patients received reirradiation with focal high dose-rate brachytherapy, and 10 received stereotactic body radiation therapy to the prostate with (8/10) or without (2/10) a simultaneous integrated boost2025-01-01T00:00:00Z2025 Dec2026-06-05T13:08:51.986Z2026-05-17T03:12:27.523ZS-EPMC125969654121620710.1016/j.adro.2025.101900