{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["168(4)"],"submitter":["Serajeddini H"],"funding":["Canada Research Chairs Program"],"pubmed_abstract":["<h4>Background</h4>Airway inflammation is a hallmark feature of asthma characterized by elevated eosinophils and/or neutrophils. Eosinophils in sputum can contribute to ventilation defects. The functional consequence of other types of cellularity on ventilation is unknown.<h4>Research question</h4>What is the effect of different sputum cellular phenotypes on abnormal ventilation evaluated by <sup>129</sup>Xe MRI in patients with severe asthma?<h4>Study design and methods</h4>Eighty-five patients with severe asthma and 15 healthy control participants underwent <sup>129</sup>Xe ventilation MRI. Sputum cytometry was performed to evaluate airway inflammation and to stratify patients with asthma into 4 cellular phenotypes (paucigranulocytic, eosinophilic, neutrophilic, and mixed-granulocytic). "],"journal":["Chest"],"pagination":["860-873"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12597553"],"repository":["biostudies-literature"],"pubmed_title":["Sputum Cellularity and MRI Ventilation Defects in Severe Asthma."],"pmcid":["PMC12597553"],"pubmed_authors":["Huang C","Zhang K","Tan NS","Kjarsgaard M","Serajeddini H","Nair P","Svenningsen S","Thakar A","Ragunayakam N","Sandhu E","Konyer N","Radford K","Mukherjee M","Venegas Garrido C","Friedlander Y"],"additional_accession":[]},"is_claimable":false,"name":"Sputum Cellularity and MRI Ventilation Defects in Severe Asthma.","description":"<h4>Background</h4>Airway inflammation is a hallmark feature of asthma characterized by elevated eosinophils and/or neutrophils. Eosinophils in sputum can contribute to ventilation defects. The functional consequence of other types of cellularity on ventilation is unknown.<h4>Research question</h4>What is the effect of different sputum cellular phenotypes on abnormal ventilation evaluated by <sup>129</sup>Xe MRI in patients with severe asthma?<h4>Study design and methods</h4>Eighty-five patients with severe asthma and 15 healthy control participants underwent <sup>129</sup>Xe ventilation MRI. Sputum cytometry was performed to evaluate airway inflammation and to stratify patients with asthma into 4 cellular phenotypes (paucigranulocytic, eosinophilic, neutrophilic, and mixed-granulocytic). ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-05T12:27:02.33Z","creation":"2026-05-16T03:12:17.461Z"},"accession":"S-EPMC12597553","cross_references":{"pubmed":["40404048"],"doi":["10.1016/j.chest.2025.05.013"]}}