biostudies-literatureUnknown18Zhongcheng L<h4>Background</h4>Primary small intestinal lymphoma (PSIL) is a rare malignancy with heterogeneous clinical and pathological features, making accurate diagnosis challenging.<h4>Objectives</h4>To investigate the clinical value of double-balloon enteroscopy (DBE) combined with endoscopic ultrasonography (EUS) in the diagnosis of small intestinal lymphoma.<h4>Design</h4>Retrospective cohort study.<h4>Methods</h4>We retrospectively reviewed 21 patients with pathologically confirmed PSIL who underwent both DBE and EUS at the Department of Small Intestinal Endoscopy, The Sixth Affiliated Hospital of Sun Yat-sen University, between September 2022 and May 2025. Clinical data were collected and analyzed in combination with pathological findings.<h4>Results</h4>A total of 21 patients were included Therapeutic advances in gastrointestinal endoscopy26317745251392785https://www.ebi.ac.uk/biostudies/studies/S-EPMC12598085biostudies-literatureEvaluating the diagnostic value of double-balloon enteroscopy combined with endoscopic ultrasonography for primary small intestinal lymphoma.PMC12598085Zhongcheng LNing SMeiying CYan ZWenru LTing XHaili WZhiyue WQin GXiaoying LfalseEvaluating the diagnostic value of double-balloon enteroscopy combined with endoscopic ultrasonography for primary small intestinal lymphoma.<h4>Background</h4>Primary small intestinal lymphoma (PSIL) is a rare malignancy with heterogeneous clinical and pathological features, making accurate diagnosis challenging.<h4>Objectives</h4>To investigate the clinical value of double-balloon enteroscopy (DBE) combined with endoscopic ultrasonography (EUS) in the diagnosis of small intestinal lymphoma.<h4>Design</h4>Retrospective cohort study.<h4>Methods</h4>We retrospectively reviewed 21 patients with pathologically confirmed PSIL who underwent both DBE and EUS at the Department of Small Intestinal Endoscopy, The Sixth Affiliated Hospital of Sun Yat-sen University, between September 2022 and May 2025. Clinical data were collected and analyzed in combination with pathological findings.<h4>Results</h4>A total of 21 patients were included 2025-01-01T00:00:00Z2025 Jan-Dec2026-06-05T13:14:15.648Z2026-05-17T03:11:38.604ZS-EPMC125980854122137810.1177/26317745251392785