{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fragassi A"],"funding":["National Institute of Arthritis and Musculoskeletal and Skin Diseases","H2020 Marie Sklodowska-Curie Actions","NIAMS NIH HHS"],"pagination":["60145-60161"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12598699"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(44)"],"pubmed_abstract":["Osteoarthritis (OA) is the most common joint disorder, characterized by a vicious cycle of synovial inflammation and cartilage degradation. Intra-articular injection of hyaluronic acid (HA)-based products, one of the currently available treatments, provides only temporary symptomatic relief without addressing the underlying inflammation. Here, we engineered several configurations of 20 × 5 μm square-shaped HA-based hydrogel microparticles (μHA) by photopolymerizing HA-methacrylate chains within a sacrificial template. The μHA mechano-pharmacological properties were tuned by adjusting the HA concentration, molecular weight, and degree of methacrylation, resulting in microparticles with a Young's modulus ranging from a few tens (30 kPa) to a few hundred (200 kPa) kilopascals; a structure sta"],"journal":["ACS applied materials & interfaces"],"pubmed_title":["Hyaluronic Acid Microplates for Intra-articular Lubrication and Cartilage Protection in Post-traumatic Osteoarthritis."],"pmcid":["PMC12598699"],"funding_grant_id":["R01 AR078666","872648"],"pubmed_authors":["Francesco MD","Soltes A","Decuzzi P","Goldoni L","Greco A","Palomba R","Yu F","Fragassi A","Kasem H","Ammar AA","Duvall C","Gonzalez De Anleo ME","Granero-Molto F","Ceseracciu L","Papa V","Keech M","Brahmachari S","D'Arcy R"],"additional_accession":[]},"is_claimable":false,"name":"Hyaluronic Acid Microplates for Intra-articular Lubrication and Cartilage Protection in Post-traumatic Osteoarthritis.","description":"Osteoarthritis (OA) is the most common joint disorder, characterized by a vicious cycle of synovial inflammation and cartilage degradation. Intra-articular injection of hyaluronic acid (HA)-based products, one of the currently available treatments, provides only temporary symptomatic relief without addressing the underlying inflammation. Here, we engineered several configurations of 20 × 5 μm square-shaped HA-based hydrogel microparticles (μHA) by photopolymerizing HA-methacrylate chains within a sacrificial template. The μHA mechano-pharmacological properties were tuned by adjusting the HA concentration, molecular weight, and degree of methacrylation, resulting in microparticles with a Young's modulus ranging from a few tens (30 kPa) to a few hundred (200 kPa) kilopascals; a structure sta","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T13:13:15.036Z","creation":"2026-05-17T03:13:18.787Z"},"accession":"S-EPMC12598699","cross_references":{"pubmed":["41076582"],"doi":["10.1021/acsami.5c11890"]}}