biostudies-literatureUnknown47(1)Fan COur study aimed at assessing the impact of β-blocker treatment on the mortality of patients with sepsis-associated acute kidney injury (SA-AKI). Clinical data for patients with SA-AKI were collected from the Medical Information Mart for Intensive Care (MIMIC)-IV database. Baseline characteristics between β-blocker users and non-users were adjusted through propensity score matching (PSM). Kaplan-Meier curves and the Cox proportional hazards model were employed to analyze the relationship between β-blocker use and mortality, with the primary outcome being 30-day mortality. This study included data from 8,620 patients, with 3,159 receiving treatment and 5,461 not. After PSM, 2,896 matched pairs were created. The analysis revealed that 30-day (hazard ratio [HR]: 0.58, 95% CI: 0.52-0.65; <i>p</Renal failure2562447https://www.ebi.ac.uk/biostudies/studies/S-EPMC12599005biostudies-literatureImpact of β-blockers on mortality in sepsis-associated acute kidney injury: a retrospective propensity score-matched analysis.PMC12599005Duan JGuo WWang HYan YZheng GFan CYang FWang LfalseImpact of β-blockers on mortality in sepsis-associated acute kidney injury: a retrospective propensity score-matched analysis.Our study aimed at assessing the impact of β-blocker treatment on the mortality of patients with sepsis-associated acute kidney injury (SA-AKI). Clinical data for patients with SA-AKI were collected from the Medical Information Mart for Intensive Care (MIMIC)-IV database. Baseline characteristics between β-blocker users and non-users were adjusted through propensity score matching (PSM). Kaplan-Meier curves and the Cox proportional hazards model were employed to analyze the relationship between β-blocker use and mortality, with the primary outcome being 30-day mortality. This study included data from 8,620 patients, with 3,159 receiving treatment and 5,461 not. After PSM, 2,896 matched pairs were created. The analysis revealed that 30-day (hazard ratio [HR]: 0.58, 95% CI: 0.52-0.65; <i>p</2025-01-01T00:00:00Z2025 Dec2026-06-05T12:25:59.393Z2026-05-16T03:11:53.512ZS-EPMC125990054102207310.1080/0886022X.2025.2562447