{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shu J"],"funding":["Training Program for Young and Middle-aged Health Science and TechnologyInnovation Leaders in Henan Province","2024 Key Scientific Research Programfor Higher Education Institutions in Henan Province","National Natural Science Foundation of China"],"pagination":["1092"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12599082"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(1)"],"pubmed_abstract":["<h4>Objective</h4>Esophageal squamous cell carcinoma (ESCC) is a lethal malignancy with limited therapeutic options, primarily due to its aggressive metastatic behavior. This study aimed to elucidate the molecular drivers of ESCC metastasis by identifying a critical oncogene and investigate its functional mechanisms.<h4>Methods</h4>Using integrated bioinformatics screening, we identified NDC80 as a potential regulator of metastasis. The role and underlying mechanisms of NDC80 in ESCC progression have remained to be fully elucidated. We conducted in vitro functional assays-including real-time PCR, western blotting, and flow cytometry-to assess the effects of NDC80 on epithelial-mesenchymal transition (EMT) and malignant behavior. Mechanistic studies such as co-culture systems and ELISA, wer"],"journal":["European journal of medical research"],"pubmed_title":["NDC80 promotes epithelial to mesenchymal transition of esophageal squamous cell carcinoma through macrophages polarization and PI3K/AKT pathway activation."],"pmcid":["PMC12599082"],"funding_grant_id":["YXKC2022015","82070222","24A310023"],"pubmed_authors":["Liu X","Zhao N","Sun M","Li Y","Chen K","Liang Y","Tabish MS","Shu J","Yang C","Sun Z"],"additional_accession":[]},"is_claimable":false,"name":"NDC80 promotes epithelial to mesenchymal transition of esophageal squamous cell carcinoma through macrophages polarization and PI3K/AKT pathway activation.","description":"<h4>Objective</h4>Esophageal squamous cell carcinoma (ESCC) is a lethal malignancy with limited therapeutic options, primarily due to its aggressive metastatic behavior. This study aimed to elucidate the molecular drivers of ESCC metastasis by identifying a critical oncogene and investigate its functional mechanisms.<h4>Methods</h4>Using integrated bioinformatics screening, we identified NDC80 as a potential regulator of metastasis. The role and underlying mechanisms of NDC80 in ESCC progression have remained to be fully elucidated. We conducted in vitro functional assays-including real-time PCR, western blotting, and flow cytometry-to assess the effects of NDC80 on epithelial-mesenchymal transition (EMT) and malignant behavior. Mechanistic studies such as co-culture systems and ELISA, wer","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-05-16T03:17:35.391Z","creation":"2026-05-16T03:12:36.753Z"},"accession":"S-EPMC12599082","cross_references":{"pubmed":["41207896"],"doi":["10.1186/s40001-025-03397-3"]}}