{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ancona P"],"funding":["Nicoletta Bianchi: University of Ferrara FONDO DI ATENEO PER LA RICERCA SCIENTIFICA (FAR)","Polish NAWA Ulam Scholarship","Stefano Volinia: MUR PNRR National Center for HPC big data and quantum computing","Poland's National Science Centre project OPUS 24"],"pagination":["3124-3149"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12599593"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["599(21)"],"pubmed_abstract":["This study, based on datasets from healthy tissues, lactating mammary epithelial cells, and breast cancer phenotypes, investigates mammary gland pathophysiology at single-cell resolution to identify key regulators in breast cancer development and to gain a deeper understanding of its biology and heterogeneity. We suggest that antileukoproteinase (SLPI) has prognostic value associated with metastasis in basal breast cancers. Our analysis highlights the similarity between triple-negative breast cancer cells and mature luminal lactocytes, which share active regulons (SOX2, MTHFD1, POU4F3, and ZNF32), suggesting conserved molecular mechanisms. Among the differences, the absence of MALAT1 and NEAT1 lncRNAs in lactocytes correlates with loss of six transcription factors (EP300, ELF1, E2F3, BDP1,"],"journal":["FEBS letters"],"pubmed_title":["From lactation to malignancy: A comparison between healthy and cancerous breast gland at single-cell resolution reveals new issues for tumorigenesis."],"pmcid":["PMC12599593"],"funding_grant_id":["CN00000013 CN1","BPN/ULM/2021/1/00232","2024 application ID 1567224","2022/47/B/NZ7/03418"],"pubmed_authors":["Bergamini CM","Ferrari C","Ancona P","Bianchi N","Volinia S"],"additional_accession":[]},"is_claimable":false,"name":"From lactation to malignancy: A comparison between healthy and cancerous breast gland at single-cell resolution reveals new issues for tumorigenesis.","description":"This study, based on datasets from healthy tissues, lactating mammary epithelial cells, and breast cancer phenotypes, investigates mammary gland pathophysiology at single-cell resolution to identify key regulators in breast cancer development and to gain a deeper understanding of its biology and heterogeneity. We suggest that antileukoproteinase (SLPI) has prognostic value associated with metastasis in basal breast cancers. Our analysis highlights the similarity between triple-negative breast cancer cells and mature luminal lactocytes, which share active regulons (SOX2, MTHFD1, POU4F3, and ZNF32), suggesting conserved molecular mechanisms. Among the differences, the absence of MALAT1 and NEAT1 lncRNAs in lactocytes correlates with loss of six transcription factors (EP300, ELF1, E2F3, BDP1,","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T12:26:53.138Z","creation":"2026-05-16T03:12:13.141Z"},"accession":"S-EPMC12599593","cross_references":{"pubmed":["40922505"],"doi":["10.1002/1873-3468.70162"]}}