{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cahillane M"],"funding":["European Blood Alliance (EBA)"],"pagination":["1123-1131"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12602124"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["120(11)"],"pubmed_abstract":["<h4>Background and objectives</h4>The Welsh Blood Service (WBS) produces pooled platelet concentrates from four buffy coats (4BC-PC), achieving consistently high platelet yields exceeding the UK specification. Three buffy coat platelet concentrates (3BC-PC) offer the potential for improved supply chain resilience and increased production capacity. Data modelling was performed to evaluate the local feasibility of 3BC-PC production.<h4>Materials and methods</h4>Platelet recovery (%) was calculated from 41 4BC-PC to generate three reference values (maximum, average and minimum). Measurements from the 164 BCs were used to model 3BC-PC production, with further analysis determining the impacts of manufacturing variability. Calculated yields were assessed against UK, European (EU) and UK continge"],"journal":["Vox sanguinis"],"pubmed_title":["Three buffy coat platelet concentrates: Use of data modelling to make more with less."],"pmcid":["PMC12602124"],"funding_grant_id":["2022-02"],"pubmed_authors":["Saunders C","Polidano N","Pearce N","Paletto L","O'Brien S","Cahillane M","George C","Scorer T"],"additional_accession":[]},"is_claimable":false,"name":"Three buffy coat platelet concentrates: Use of data modelling to make more with less.","description":"<h4>Background and objectives</h4>The Welsh Blood Service (WBS) produces pooled platelet concentrates from four buffy coats (4BC-PC), achieving consistently high platelet yields exceeding the UK specification. Three buffy coat platelet concentrates (3BC-PC) offer the potential for improved supply chain resilience and increased production capacity. Data modelling was performed to evaluate the local feasibility of 3BC-PC production.<h4>Materials and methods</h4>Platelet recovery (%) was calculated from 41 4BC-PC to generate three reference values (maximum, average and minimum). Measurements from the 164 BCs were used to model 3BC-PC production, with further analysis determining the impacts of manufacturing variability. Calculated yields were assessed against UK, European (EU) and UK continge","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T15:11:27.214Z","creation":"2026-05-18T03:13:05.361Z"},"accession":"S-EPMC12602124","cross_references":{"pubmed":["40789580"],"doi":["10.1111/vox.70090"]}}