biostudies-literatureCahillane MEuropean Blood Alliance (EBA)1123-1131https://www.ebi.ac.uk/biostudies/studies/S-EPMC12602124biostudies-literatureUnknown120(11)<h4>Background and objectives</h4>The Welsh Blood Service (WBS) produces pooled platelet concentrates from four buffy coats (4BC-PC), achieving consistently high platelet yields exceeding the UK specification. Three buffy coat platelet concentrates (3BC-PC) offer the potential for improved supply chain resilience and increased production capacity. Data modelling was performed to evaluate the local feasibility of 3BC-PC production.<h4>Materials and methods</h4>Platelet recovery (%) was calculated from 41 4BC-PC to generate three reference values (maximum, average and minimum). Measurements from the 164 BCs were used to model 3BC-PC production, with further analysis determining the impacts of manufacturing variability. Calculated yields were assessed against UK, European (EU) and UK contingeVox sanguinisThree buffy coat platelet concentrates: Use of data modelling to make more with less.PMC126021242022-02Saunders CPolidano NPearce NPaletto LO'Brien SCahillane MGeorge CScorer TfalseThree buffy coat platelet concentrates: Use of data modelling to make more with less.<h4>Background and objectives</h4>The Welsh Blood Service (WBS) produces pooled platelet concentrates from four buffy coats (4BC-PC), achieving consistently high platelet yields exceeding the UK specification. Three buffy coat platelet concentrates (3BC-PC) offer the potential for improved supply chain resilience and increased production capacity. Data modelling was performed to evaluate the local feasibility of 3BC-PC production.<h4>Materials and methods</h4>Platelet recovery (%) was calculated from 41 4BC-PC to generate three reference values (maximum, average and minimum). Measurements from the 164 BCs were used to model 3BC-PC production, with further analysis determining the impacts of manufacturing variability. Calculated yields were assessed against UK, European (EU) and UK continge2025-01-01T00:00:00Z2025 Nov2026-06-05T15:11:27.214Z2026-05-18T03:13:05.361ZS-EPMC126021244078958010.1111/vox.70090