biostudies-literatureUnknownZerna CBackgroundTo compare the benefit of endovascular treatment(EVT) in acute ischemic stroke(AIS) patients with large vessel occlusion(LVO) presenting > 6 h from last known well outside a clinical trial setting to best medical management and to EVT in a randomized trial setting.MethodsData from a retrospective multicenter cohort study (ESCAPE-LATE) of AIS-LVO patients treated with EVT beyond 6 hours from last known well at former ESCAPE trial sites were pooled with historical data from ESCAPE trial late time window patients. Unadjusted and adjusted 90-day modified Rankin Scale (mRS) score was compared between ESCAPE-LATE patients, ESCAPE late time window EVT arm and control arm patients.ResultsA total of 249 patients were included in the analysis: 200 ESCAPE-LATE patients (for 141 of whom 90-dInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences15910199251347782https://www.ebi.ac.uk/biostudies/studies/S-EPMC12602283biostudies-literatureEndovascular treatment vs. best medical management for late window ischemic stroke patients with large vessel occlusion.PMC12602283Puetz Vvan Adel BGraham BYu AYHill MDMcTaggart RAFrei DFHarrison EPereira VKaiser DPGoyal MShankar JJZerna CKleinig TJOspel JfalseEndovascular treatment vs. best medical management for late window ischemic stroke patients with large vessel occlusion.BackgroundTo compare the benefit of endovascular treatment(EVT) in acute ischemic stroke(AIS) patients with large vessel occlusion(LVO) presenting > 6 h from last known well outside a clinical trial setting to best medical management and to EVT in a randomized trial setting.MethodsData from a retrospective multicenter cohort study (ESCAPE-LATE) of AIS-LVO patients treated with EVT beyond 6 hours from last known well at former ESCAPE trial sites were pooled with historical data from ESCAPE trial late time window patients. Unadjusted and adjusted 90-day modified Rankin Scale (mRS) score was compared between ESCAPE-LATE patients, ESCAPE late time window EVT arm and control arm patients.ResultsA total of 249 patients were included in the analysis: 200 ESCAPE-LATE patients (for 141 of whom 90-d2025-01-01T00:00:00Z2025 Nov2026-06-05T15:13:39.192Z2026-05-18T03:12:29.24ZS-EPMC126022834121251810.1177/15910199251347782