biostudies-literatureRamachandran DStanford UniversityEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentStanford University, Department of Obstetrics and GynecologyMedizinische Hochschule Hannover (MHH)NICHD NIH HHSDeutsche ForschungsgemeinschaftMedizinischen Hochschule HannoverStanford Maternal and Child Health Research Institute3275-3289https://www.ebi.ac.uk/biostudies/studies/S-EPMC12602745biostudies-literatureUnknown42(10)<h4>Purpose</h4>Observational data suggest that women conceiving without a corpus luteum are at higher risk of developing preeclampsia. While the underlying mechanisms remain unclear, the absence of corpus luteum-derived secretory products may be a contributing factor. This study investigates whether the plasma proteome differs between women who conceive with or without a corpus luteum and examines the relationship with mode of conception.<h4>Methods</h4>Plasma samples from 12 participants were collected at three time points: first trimester, third trimester, and postpartum. The cohort included women who conceived unassisted (UC) after infertility, via artificial cycle frozen embryo transfer (AC FET), or natural cycle frozen embryo transfer (NC FET). A total of 36 plasma protein samples weJournal of assisted reproduction and geneticsExploring the plasma proteome linked to corpus luteum presence and conception mode across pregnancy stages and postpartum.PMC12602745Division of Maternal-Fetal MedicineArlineH&amp;H Evergreen Faculty Scholar507276351273703678Pete Harman Faculty ScholarP01 HD 065647-01A1Institutional fundsH&H Evergreen Faculty ScholarObstetrics Research FundsP01 HD065647Ramachandran DSchroder-Heurich BDewender RTFrobose WPich AWinn VDBaker VLRichter KAvdulahu Fvon Versen-Hoynck FfalseExploring the plasma proteome linked to corpus luteum presence and conception mode across pregnancy stages and postpartum.<h4>Purpose</h4>Observational data suggest that women conceiving without a corpus luteum are at higher risk of developing preeclampsia. While the underlying mechanisms remain unclear, the absence of corpus luteum-derived secretory products may be a contributing factor. This study investigates whether the plasma proteome differs between women who conceive with or without a corpus luteum and examines the relationship with mode of conception.<h4>Methods</h4>Plasma samples from 12 participants were collected at three time points: first trimester, third trimester, and postpartum. The cohort included women who conceived unassisted (UC) after infertility, via artificial cycle frozen embryo transfer (AC FET), or natural cycle frozen embryo transfer (NC FET). A total of 36 plasma protein samples we2025-01-01T00:00:00Z2025 Oct2026-06-05T15:13:47.684Z2026-05-18T03:12:33.59ZS-EPMC126027454097447110.1007/s10815-025-03632-0