{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(10)"],"submitter":["Vaca-Cartagena BF"],"pubmed_abstract":["<h4>Background</h4>Lung volume reduction surgery (LVRS) is an effective treatment for patients with severe emphysema. Most studies favor a bilateral approach over unilateral LVRS. However, there is limited literature comparing the outcomes of sequential bilateral \"staged\" versus simultaneous bilateral LVRS. Here, we evaluated the safety and effectiveness of these two approaches.<h4>Methods</h4>This retrospective cohort study included patients with severe emphysema who underwent LVRS at two tertiary referral centers. Pre- and postoperative-pulmonary function tests were used to assess outcomes. Descriptive statistics were used to explore associations between variables. For our survival analysis, we created a composite outcome combining overall survival and transplant-free survival, which was"],"journal":["Journal of thoracic disease"],"pagination":["7711-7723"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12603395"],"repository":["biostudies-literature"],"pubmed_title":["Evaluating the effectiveness of staged versus simultaneous bilateral lung volume reduction surgery in patients with severe emphysema."],"pmcid":["PMC12603395"],"pubmed_authors":["Abia-Trujillo D","Al-Botros LM","Vaca-Cartagena BF","Alomari M","Thomas M","Fernandez-Bussy S","Castillo-Larios R","Khaled Khalifa HE","Shah SZ","Makey IA","Lee-Mateus AY","Narula T"],"additional_accession":[]},"is_claimable":false,"name":"Evaluating the effectiveness of staged versus simultaneous bilateral lung volume reduction surgery in patients with severe emphysema.","description":"<h4>Background</h4>Lung volume reduction surgery (LVRS) is an effective treatment for patients with severe emphysema. Most studies favor a bilateral approach over unilateral LVRS. However, there is limited literature comparing the outcomes of sequential bilateral \"staged\" versus simultaneous bilateral LVRS. Here, we evaluated the safety and effectiveness of these two approaches.<h4>Methods</h4>This retrospective cohort study included patients with severe emphysema who underwent LVRS at two tertiary referral centers. Pre- and postoperative-pulmonary function tests were used to assess outcomes. Descriptive statistics were used to explore associations between variables. For our survival analysis, we created a composite outcome combining overall survival and transplant-free survival, which was","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-05T15:15:14.462Z","creation":"2026-05-18T03:13:01.18Z"},"accession":"S-EPMC12603395","cross_references":{"pubmed":["41229759"],"doi":["10.21037/jtd-2025-790"]}}